姜黄素对糖尿病大鼠糖、脂代谢及氧化应激的影响

Effect of curcumin on glucose and lipid metabolism and oxidative stress in diabetic rats

目的 观察姜黄素对糖尿病大鼠糖、脂代谢及氧化应激的影响。方法 链脲佐菌素 (STZ)诱导糖尿病大鼠模型 ,并随机分为糖尿病组和姜黄素治疗组 ,另设一正常对照组 ,治疗组灌胃给予姜黄素 2 0 0mg·kg-1·d-1,为期 8周。然后进行血糖、血脂及抗氧化指标的检测。结果 与正常对照组大鼠比较 ,糖尿病组大鼠血胆固醇、甘油三酯、低密度脂蛋白 -胆固醇明显增高 (P<0 .0 1,P <0 .0 5 ,P <0 .0 1) ,而高密度脂蛋白 胆固醇明显降低 (P <0 .0 5 ) ;血清超氧化物歧化酶、过氧化氢酶活性显著降低 ,丙二醛含量明显增加 (均P <0 .0 1)。姜黄素治疗组上述异常均明显减轻。糖尿病组大鼠血糖和糖化血红蛋白明显高于正常组 (均P<0 .0 1) ,姜黄素治疗组较糖尿病组虽有所下降 ,但差异无显著性。结论 姜黄素能有效纠正糖尿病大鼠脂代谢紊乱 ,减轻氧化应激水平。

Objective To observe the effect of curcumin on glucose and lipid metabolism and oxidative stress in diabetic rats. Methods Diabetic model was induced by a single intraperitoneal injection of streptozoticin(STZ) to male Wistar rats at a dose of 60mg/kg body weight and was randomly divided into two groups: untreated diabetes (group DM,n=10) and diabetes treated with curcumin 200mg·kg -1 ·d -1 (group Cur,n=10). A normal control group(group normal,,n=10) was also designed.After treated for eight weeks,the levels of blood glucose(BG) and glycosylated hemoglobin(GHb, HbA1c),serum total cholesterol(TC) ,triglyceride(TG),low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), MDA and activities of superoxide dismutase (SOD) and catalase (CAT) were evaluated.Results The levels of serum TC,TG and LDL-C were all significantly increased in diabetic rats as compared with normal rats(P<0.01,P<0.05,P<0.01), while the level of HDL-C was lower than that in normal group(P<0.05); the activities of SOD and CAT were lower and MDA level was higher in diabetic rats than those in normal group(both P<0.01). All these abnormalities were ameliorated when treated with curcumin. The levels of BG and HbA1c in diabetic rats were significantly higher than those in normal rats(both P<0.01), there was some decline of them while treated with curcumin as compared with group DM ,but had no significant discrepancy. Conclusion Curcumin can effectively correct the disorder of lipid metabolism and inhibit oxidative stress in diabetic rats.