1Beuers U.Bilzer M,Chittattu A,et a1.Tauroursodeoxycholic acid inserts the apical conjugate export pump,Mrp2,into canalicular membranes and stimulates organicanion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver[J].Hepatology,2001,33(5):1206.
2Lazaridis KN,Gores GJ,landor KD.Ursodeoxycholic acid mechanisms of action and clinical use inhepatobiliary disorders[J].J Hepatol,2001,35:134.
3Sola S。Gastro RE,Kren BT,et a1.Modulation of nuclear steroid receptors by ursodeoxychonc acid inhibits TGF-betal-induced E2F 1/p53-mediated apoptosis of rat hepatocytes[j].Biochemestry,2004,43(26):8429.
5Geetha A。Parameswari S.Effect of ursodeoxycholic acid on hydrogen peroxide induced lipid peroxidation in sheep liver mitochondria[J].Indian J Physiol Pharmacol,2002,46(3):343.
6Mitsuyoshi H。Nakashima T,Sumida Y,et a1.Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants[J].Biochem Biophys Res Commun.1999,263(2):537.
7Serrano MA.Brites D。I。arena MG,et a1.Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the placenta[J].J Hepatol,1998,28:829.
8Serrano MA。Macias RI,Vallejo M,et a1.Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway [J].J Pharmacol Exp Ther,2003,305(2):515.
9Reyes H,Sjovall J.Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy[J].Ann Med.2000,32(2):94.
10Fickert P。Z011ner G,Fuchsbichler A,et a1.Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver[J].Gastroenterology,2001,121:170.