FK506和环孢素A对肾移植患者血脂影响的比较

The effects comparison of FK506 and CsA on serum lipids in renal allograft recipients

目的:比较FK506 和环孢素 A(CsA)对肾移植患者术后脂质代谢的影响。方法:将以 FK506 或CsA为主要免疫抑制剂的肾移植患者209例分成FK506组和 CsA组,对两组术后 3 个月、6 个月和 1 年的血脂变化进行比较。结果:CsA组治疗术后血脂增高的比例均明显高于 FK506 组,且 CsA组患者的治疗前、后血脂水平亦有明显差异。结论:肾移植患者治疗应用FK506比CsA可能会有效地降低高脂血症的发生率。

Objective:Objectives: To compare the effects between tacrolimus (FK506) and cyclosporin(CsA) on serum lipids after renal transplantation.Methods:There were 209 renal recipients involved in this study, among which 116 on CsA treatment and 93 on tacrolimus treatment. Main follow-up time was three month, six month and one year after operation. Chi-square test was used during statistical analysis.Results:No significant difference of the serum lipids mean levels was found between two groups before operation. The percentage of patients with hyperlipidemia in CsA group was significantly higher than that in FK506 group in the three-month, six-month and one-year follow-up. Moreover, there are staring difference among various time in CsA group.Conclusions:FK506 may be superior to CsA with respect to its effect on serum lipids.