贵州从江侗族人群β-地中海贫血调查

Investigation of β-thalassemia in Dong people of Congjiang, Guizhou

目的调查β-地中海贫血在贵州从江侗族人群的发病情况,了解该病在贵州少数民族中的分布特点。方法抽取受检者静脉血,应用抗碱血红蛋白(HbF)和血红蛋白A2(HbA2)定量测定对人群进行β-地中海贫血初筛,同时应用全自动血细胞分析仪进行RBC、Hb、HCT、MCV、MCH、MCHC、RDW等7项血液学指标分析。结果在497例从江侗族受检人群中,β-地中海贫血的检出率为7.85% ,男女比例为1.17∶1 。结论该地区侗族人群中β-地中海贫血患病率较高,高于同地区其他民族,这可能与他们的婚俗习惯和自身民族特点有关。

Objective To investigate the incidence of β-thalassemia in Dong people, a minority living in Congjiang, Guizhou. Methods Venous blood was collected and Hb F and HbA2 were determined by AM-electrophoresis to screen the carriers of β-thalassemia, whose blood were analyzed by automatic blood cell analyzer. Results Among the 497 samples, the incidence of β-thalassemia carriers was 7.85%, the proportion of male and female was 1.17∶1. Conclusions We get the information that the incidence of β-thalassemia Dong people in Guizhou is higher than that of other people in the same area, which might be related to their ethnic marriage and ethnic feature.