铜、铁离子在癌形成中的作用

The role of copper and iron ion in carcinogenesis

目的 :研究铜离子、铁离子在癌形成中的作用。方法 :测定96例癌症患者和36例健康对照血清中脂质过氧化物 (MDA)浓度、血清Cu、Fe离子浓度及总抗氧化力水平。结果 :本测定结果显示 :癌症患者MDA水平明显高于对照 ,癌症患者111例 (5 21±1 05)nmol/L;对照组36例 (4 04±0 68)nmol/L,两组比较P<0 001。总抗氧化力明显低于对照 ,癌症患者组 (4 39±0 98)U/L;对照组(5.78±0.93)U/L,(P<0 001)。两组比较癌症患者血清水平明显增高 (19.72±4.74)μmol/L;对照组 (14.92±2.71)μmol/L,两组比较P<0 001,但血清铁水平无显著变化。结论 :铜、铁离子可促进反应性氧类 (ROS)的产生 ,引发和 (或 )加速正常细胞恶性 ,促进癌的形成。

Objective:To study the role of copper and iron ion in carcinogen esis.Methods:The concentrations of malondialdehyde(MDA),copper and iron ion and the serum level of total antioxidation power in 111 cancer patients and 36 healt hy people as controls were measured respectively.Results:The results of this stu dy showed that the concentration of MDA in cancer patients was significantly hig her than that in control group(5.21±1.05 nmol/L vs 4.04±0.68 nmol/L,P<0.001),t he serum level of total antioxidation power in cancer patients was significantly lower than that in control group(4.39±0.98 U/L vs 5.78±0.93 U/L,P<0.01).Compa red with the control group,the serum concentration of copper ion in cancer patie nts was significantly increased(19.72±4.74 μmol/L vs 14.92±2.71 μmol/L,P<0.0 01),however the concentration of iron ion was no significant difference.Conclusi on:Copper and iron ion may increase ROS production,which can trigger malignizati on of normal cell and promote carcinogenesis.