绝经后妇女血清激素水平的改变与骨质疏松症的早期诊断和危险度预测

Prognosis of osteoporosis by changes in serum levels of some related hormones in postmenopausal women

目的分析绝经后正常和骨质疏松妇女骨代谢相关激素血清水平的改变,探讨和骨质疏松关系密切的激素,预测骨质疏松症的危险度和早期诊断。方法57名绝经3年以上的妇女,测量腰椎骨密度,分为骨质疏松组(30例)和对照组(27例)。隔夜空腹取血测定血清LH,FSH,E2,DHEA,DHEAS,SHBG,CT,PTH,25(OH)2D3,分析其血清水平的改变和骨质疏松的关系。结果绝经后妇女骨质疏松组和对照组在年龄上没有差异(578±467&581±523)。绝经后妇女血清E1,DHEA,DHEAS的水平和年龄负相关。骨质疏松组和对照组相比,LH,SHBG显著增高(P<005),DHEA,DHEAS,CT显著降低(P<005),其他指标没有显著性差异。结论绝经后妇女骨代谢相关激素水平的改变和骨质疏松症的发病有着密切的关系。检测该变化可以有效的早期诊断骨质疏松症和预测其危险度。

Objective To study the changes of some related hormones in postmenopausal osteoporosis to prognose osteoporosis. Methods 50 postmenopausal women were assigned to pateoporosis group(n=30), and the control group(n=27). The serum levels of LH, FSH, E1, SHBG, DHEA, DHEA-S, CT, PTH, 25(OH) D_3 were measured after overnight fasting. Results The LH and SHBG level in osteoporosis group were higher than those in control group. DHEA,DHEA-S and CT levels were lower. There were no significant differences inFSH,CT,PTH, 25(OH)D_3, PRL,E1 a between the two groups. Conclusion These hormones have consanguineous relationship with osteoporosis.The measurement of such change is helpful for diagnosis and prognosis of osteoporosis.