P16、P53、Bcl-2表达,Ki-67标记指数与胸腺瘤侵袭性及预后的关系

P16, P53, Bcl-2 expression and Ki-67 labelling index correlations with invasiveness and prognosis in thymoma

目的探讨P16、P53、Bcl2表达,Ki67标记指数与胸腺瘤侵袭性及预后的关系。方法应用免疫组化染色方法检测41例胸腺瘤患者P16、P53、Bcl2、Ki67的表达。结果胸腺瘤P16、P53、Bcl2阳性表达率分别为488%、585%、415%,Ki67标记指数(Ki67LI)为955%±675%。P16、Bcl2蛋白表达与胸腺瘤的侵袭性和预后均无关系。P53蛋白表达和Ki67LI与胸腺瘤侵袭性相关(P<005,P<001),Ki67LI还与胸腺瘤预后有关(P<005)。结论P53蛋白表达和Ki67LI可为侵袭性胸腺瘤诊断提供依据,Ki67LI还可作为估计胸腺瘤预后的参考指标。

Objective To study P16, P53 and Bcl-2 expression and Ki-67 labelling index correlations with invasiveness and prognosis in thymoma. Methods P16, P53, Bcl-2 expression and Ki-67 labelling index in 41 thymomas were examined immunohistochemically. Results P16, P53 and Bcl-2 positive rate in thymoma were 48.8%、58.5% and 41.5%, respectively. Ki-67 LI为9.55%±6.75%. P16、Bcl-2 expressions were not associated with invasiveness and prognosis of thymoma. P53 expression and Ki-67 LI correlated with the invasion of thymoma(P<0.05,P<0.01), moreover, Ki-67 LI correlated with the prognosis of thymoma(P<0.05). Conclusion P53 expression and Ki-67 LI can help differntiate invasive thymoma. Ki-67 LI is a good indicator for prognosis of thymomas.