GDF-8基因研究进展

Advances in the Study of GDF-8 Gene

GDF-8基因是TGF-β基因超家族成员之一,在胚胎和成体骨骼肌的增殖分化、发育中起重要作用。其表达产物myostalin被认为是体内重要的肌肉生长抑制因子。本文对国外关于GDF-8基因的研究进展,特别对GDF-8基因定位、基因结构、功能及其表达调控机制进行综述。

GDF-8 gene, a member of the TGF-β superfamily, is a negative regulator of muscle growth. It plays a vital role in the proliferation and differentiation of embryonic or adult skeletal muscle. Here, we summarized the late advances in the study of GDF-8 gene, especially in the research on location, structure, function of this gene as well as the regulation of its expression especially in the research of this gene's location, structure, function as well as the regulation of its expression.