老年患者抗生素相关性腹泻序贯治疗36例对照研究

Sequential therapy of antibiotic-associated diarrhea in the elderly:36 cases control study

目的 探讨老年患者抗生素相关性腹泻有效、经济的治疗方法。方法 将 36例患抗生素相关性腹泻的老年病人用甲硝唑、制菌霉素、双歧杆菌序贯治疗 (序贯治疗组 )的疗效与先前用去甲万古霉素、甲硝唑、双歧杆菌常规治疗 (常规治疗组 )的 33例同类病人比较。结果 序贯治疗组的有效率为 97.2 % ,常规治疗组的有效率为 84 .8% ,两组差异有统计学意义 (P <0 0 5 )。序贯治疗组的复发率为 2 9% ,常规治疗组的复发率为 2 1 4 % ,两组差异显著 (P <0 0 2 5 )。两组治愈需要的时间分别为 (14 3± 2 6 )d和 (18 5± 9 1)d ,差异有显著性意义 (P<0 0 5 )。序贯治疗组的效价比更高 ,两组差异有显著性意义 (P <0 0 0 1)。结论 用甲硝唑、制菌霉素、双歧杆菌序贯治疗老年病人的抗生素相关性腹泻的疗效较常规治疗组好 ,效价比更高。

Objective To explore the effective and economical therapy of antibiotic-associated diarrhea in the elderly.Methods 36 elderly cases suffering from antibiotic-associated diarrhea were treated by Metronidazole,Mycostatin,Bifidobacterium sequentially(Sequential therapy group).The 33 similar cases were formerly treated by Demethylvancomycin,Metronidazole,Bifidobacterium routinely(Routine therapy group).Compare the efficacy and the time needed for the therapy in two groups.Compare the rate of recurrence of the disease in two groups.Compare the ratio of effect to price.Results The efficacy of the sequential therapy group was 97.2%,but routine therapy group was 84.8%.The differences in two groups were significant (P<0.05).The rate of recurrence of the disease in sequential therapy group was 2.9%,but in routine therapy group 21.4%.The differences in two groups were significant (P<0.025).The time of cure in sequential therapy group was 14.3±2.6 days,but the routine therapy group 18.5±9.1days.The differences in two groups were significant (P<0.05).The ratio of effect to price in the sequential therapy group was higher than that in the routine therapy group(P<0.001).Conclusion The effects of antibiotic-associated diarrhea treated by Metronidazole,Mycostatin,Bifidobacterium sequentially in the elderly is better than that by routine therapy used formerly.The ratio of effect to price in the sequential therapy group is higher than that in the routine therapy group.