注射用蒺藜皂苷的抗血栓形成作用

Antithrombosis of Gross Saponin of Tribulus Terrestris injection

目的 :研究注射用蒺藜皂苷 (GSTT)对体内外血栓形成的影响。方法 :1采用动 -静脉旁路血栓形成法、电刺激动脉血栓形成法和体外血栓法 ,观察 GSTT对体内血栓湿重、血栓形成时间以及体外血栓长度和干、湿重的影响 ;2建立血瘀模型 ,观察 GSTT对血瘀大鼠全血高切、低切粘度的影响。结果 :1GSTT2 0 .8和31.2 mg· kg- 1可降低血栓湿重 (P<0 .0 5或 P<0 .0 1) ,延长血栓形成时间 (P<0 .0 1) ,缩短体外血栓长度(P<0 .0 5 ) ,降低体外血栓湿重和干重 (P<0 .0 1或 P<0 .0 5 ) ;2 GSTT2 0 .8和 31.2 m g· kg- 1可明显降低血液黏度 (P<0 .0 1)。结论 :GSTT具有抗血栓形成作用 ,其机制与降低血液黏度、改善血液流变性有关。

Objective To study the effects of Gross Saponins of Tribulus Terrestris (GSTT) on thrombosis in vivo and in vitro. Methods ①The effects of GSTT on thrombus wet weight and thrombosis time of rats in vivo and the thrombus length, thrombus wet and dry weight in rats in vitro were observed by using the methods of neck artery-vein side-way thrombosis and artery thrombosis induced by electricity stimulation.②The effects of GSTT on the blood viscosity in blood stasis rats were observed. Results ①GSTT with doses of 20.8 and 31.2 mg·kg -1 could significantly decrease thrombus wet weight (P<0.05 or P<0.01), and prolong thrombosis time (P<0.01), and shorten the thrombus length in vitro(P<0.05), and decrease thrombus wet and dry weight in vitro (P<0.01 or P<0.05). ②GSTT with doses of 20.8 and 31.2 mg·kg -1 can significantly decrease blood viscosity (P<0.01).Conclusion GSTT has the effects of antithrombosis, and its mechanism is related to lowering blood viscosity and improving blood hemorheology.