注射用蒺藜皂苷对麻醉开胸犬急性心肌梗塞的保护作用

Protective effects of Gross Saponin of Tribulus Terrestris on anaes-thetic thoraco-opened dogs with acute myocardial infarction

目的 :研究注射用蒺藜皂苷 (GSTT)对麻醉开胸犬结扎冠脉所致急性心肌梗塞的保护作用。方法 :取杂种犬 30只 ,随机分为 5组 (每组 6只 ) ,分别为空白对照组、血塞通 (阳性对照药物 )组及 GSTT 6 .2 6、 12 .5 2和 2 5 .0 m g· kg- 1 剂量组 ;结扎左冠状动脉前降支 ,制备急性心肌梗塞模型 ,观察 GSTT对心外膜电图 (EECG)、心肌梗塞范围和血清心肌酶的影响。结果 :GSTT各剂量组与空白对照组比较心肌缺血程度减轻 (P<0 .0 5 ) ,缺血范围缩小 (P<0 .0 5 ) ,血清酶降低 (P<0 .0 1) ,心肌梗塞面积缩小 (P<0 .0 0 1)。结论 :GSTT对麻醉开胸犬急性心肌梗塞的心肌缺血具有明显的保护作用。

Objective To study the effects of Gross Saponin of Tribulus Terrestris (GSTT) on acute myocardial infarction induced by ligating coronary artery in anaesthetic thoraco-opening dogs by injection. Methods Thirty domestic dogs were randomly divided into 5 groups (6 in each group): blanking control group, positive control group(Xuesaitong), GSTT groups with doses of 6.26 , 12.52, and 25.0 mg·kg -1, respectively. The descending branch of left coronary artery was ligated to construct the model of acute myocardial infarction. The effects of GSTT on epicardium electrocardiogram(EECC), myocardial infarction range(MIS) , and serum myocardium enzyme were observed. Results The ischemia degree(Σ-ST, P<0.05) and the ischemia area(N-ST, P<0.05) were reduced in GSTT groups with various doses compared with controls. In addition, GSTT reduced the serum myocardium enzyme levels (P<0.01) and myocardial infarction ranges(P<0.001) compared with controls. Conclusion GSTT can significantly protect ischemic myocardium of the anesthetic thoraco-opening dogs mediated by ligating coronary artery.