颗粒溶素

Granulysin

颗粒溶素 (GNLY)是细胞毒颗粒蛋白 ,与穿孔素和颗粒酶共同定位于人的细胞毒T淋巴细胞 (CTL)和自然杀伤细胞 (NK)溶细胞颗粒中 ,也释放至健康人和患者外周血中。GNLY是机体抵抗多种病原微生物和杀灭肿瘤细胞的重要物质。血清GNLY水平可反映生理、病理状态下CTL和NK的活性 ,可作为器官移植急性排斥和宿主细胞免疫状态的新指标。

Granulysin is a cytotoxic granule protein,colocalizes with perforin and granzymes in the cytolytic granules of human CTL and NK cells. The released granulysin was found in the sera of healthy individuals and patients. Granulysin exhibits potent cytotoxic activity against tumors and a broad panel of microbes, including bacteria, fungi, and parasites. The serum levels of granulysin is well associated with diverse activities of NK cells and CTL in physiological and pathological settings and could be a useful novel serum marker for acute rejection of grafts and the overall status of host cellular immunity.