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阿德福韦在乙型肝炎中的应用现状 被引量：7

Current application status of adefovir in hepatitis B
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摘要 0引言 乙型肝炎病毒(HBV)不仅可形成急、慢性病毒性肝炎,而且与肝纤维化、肝细胞癌的发生、发展密切相关.目前对慢性乙型肝炎有两种基本的治疗方法,一种是免疫激活治疗如干扰素,另一种是抑制病毒复制如核苷类似物.阿德福韦作为一种新的抗HBV感染的核苷酸类似物已经于2002-09经FDA批准在美国上市,目前在我国正在进行3期临床实验.本文就阿德福韦的研究现状及临床观察作一综述.
作者 党晓燕 成军 邓红 张黎颖
机构地区 中国人民解放军第 西安交通大学第二医院传染科
出处 《世界华人消化杂志》 CAS 北大核心 2005年第1期61-63,共3页 World Chinese Journal of Digestology
基金 国家自然科学基金资助项目 No.C39970674 No.C03011402
关键词 阿德福韦 慢性乙型肝炎 治疗 FDA批准 核苷酸类似物 抗HBV 乙型肝炎病毒 引言 中国 美国
分类号 R512.62 [医药卫生—内科学]
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参考文献18

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同被引文献35

  • 1张定凤.乙型肝炎抗病毒治疗研究最新进展——美国肝脏病学会2004年年会纪要[J].中华肝脏病杂志,2004,12(12):708-710. 被引量：5
  • 2曾民德,茅益民,姚光弼,周霞秋,王豪,徐道振,姚集鲁,侯金林,王宇明,任红,陈亚岗,牛俊奇,王耀宗.阿德福韦酯治疗HBeAg阳性的中国慢性乙型病毒性肝炎患者52周的多中心临床研究[J].中华传染病杂志,2005,23(6):387-394. 被引量：164
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  • 7Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long - term therapy with adefovir dipivoxil for HBeAg - negative chronic hepatitis B[J]. N Engl J Med,2005,352(26):2673 -2681.
  • 8Colonno R, Rose R, Levine S, et al. Entecavir two year resistance update:no resistance observed in nucleoside native patients and low frequency resistance emergence in lamivudine refractory patients[ J]. Hepatology, 2005,42( 1 ) : 3534.
  • 9Hadziyannis SJ, Jassopllulos NC, Heathcote EJ, et al. Long - term therapy with adefovir dipivoxil for HBeAg - negative chronic hepatitis B[J]. N Engl J Med,2005,352(26) :2673 -2681.
  • 10Hadziyannis S,Tassopoulos N, Chang TT, et al. Long - term adefovir dipivoxil treatment induces regression of liver fibrosis in patients with HBe - negative chronic hepatitis B: Results after 5 years of therapy[ J]. Hepatology ,2005,42( 1 ) : 754 A.

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世界华人消化杂志
2005年 第1期

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