子宫内膜癌组织中Bim蛋白表达及其临床意义

Expression of Bim in Endometrial Carcinoma and Its Clinical Significances

目的:探讨促凋亡基因Bim在子宫内膜癌发生与发展中的作用。方法:应用免疫组化SP方法检测11例正常增殖期子宫内膜、13例非典型增生子宫内膜及55例子宫内膜癌Bim蛋白的表达。结果:在子宫内膜癌组织Bim表达阳性率为47.2%,明显低于正常增殖期内膜组织(100%)及非典型增生内膜组织(76.9%),三者之间比较有显著差异(字2=7.944,P<0.05)。而在子宫内膜癌各组织分级、临床分期及肌层浸润程度之间,Bim蛋白表达阳性率均无明显差异(P>0.05)。结论:Bim蛋白表达改变与子宫内膜癌的发生密切相关。

Objective: To study the effect of Bim on the genesis and progression of endometrial carcinoma. Methods: Expression of Bim was evaluated by immunohistochemistry (SP) in 55 cases of endometrial carcinoma, 13 cases of atypical hyperplasia endometrium and 11 cases of normal proliferative stage endometrium. Results: The positive rate of Bim expression in endometrial carcinoma is 47.2%,which is lower than that in in normal proliferative endometrium (100%) and that in atypical hyperplasia endometrium (76.9%). The difference between them is significant (?字2=7.944, P<0.05), but there is no difference among different histological grades?clinical stages and muscle invasions of endometrial carcinoma (P>0.05). Conclusions: There is a close relationship between the occurrence of endometrial carcinoma and the change of expression of Bim.