摘要
The new fused quinazoline spiro-heterocyclic compounds were synthesized by combining the fused thiazolidone and quinazoline structure with spiro-heterocyclic structure for the purpose to get novel bio-active compounds. Dipolar azomethine ylides reacted with dipolarphile 2-arylmethylene-9-benzylidene-5-phenyl-6,7,8,9-tetrahydro-5H-thiazolo[2,3-b]quinazoline-3-one via 1,3-dipolar cycloaddition to give nine fused quinazoline spiro-heterocyclic compounds. The configuration and conformation of the products were determined by elementary analysis, 1H NMR, IR and X-ray crystal analysis. The results also revealed that the reaction was stereospecific.
The new fused quinazoline spiro-heterocyclic compounds were synthesized by combining the fused thiazolidone and quinazoline structure with spiro-heterocyclic structure for the purpose to get novel bio-active compounds. Dipolar azomethine ylides reacted with dipolarphile 2-arylmethylene-9-benzylidene-5-phenyl-6,7,8,9-tetrahydro-5H-thiazolo[2,3-b]quinazoline-3-one via 1,3-dipolar cycloaddition to give nine fused quinazoline spiro-heterocyclic compounds. The configuration and conformation of the products were determined by elementary analysis, 1H NMR, IR and X-ray crystal analysis. The results also revealed that the reaction was stereospecific.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2005年第2期270-272,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :2 0 3 760 5 9)
国家"八六三"计划 (批准号 :2 0 0 2 AA3 2 5 0 5 0 )资助
关键词
螺杂环
甲亚胺叶立德
环加成
合成
Spiro-heterocycle
Azomethine ylide
Cycloaddition
Synthesis
