早期免疫干预高危哮喘儿的γ-干扰素、白细胞介素及IgE的变化研究

Changes of Serum IFN-γ,IL and IgE after Early Immune Interference in Children with Asthma Tendency

目的观察高危哮喘儿早期流感疫苗、肺炎疫苗及免疫增强剂斯奇康免疫干预后的γ-干扰素(IFN-γ)、白细胞介素2(IL-2)、白细胞介素5(IL-5)、白细胞介素10(IL-10)及免疫球蛋白IgE水平变化,评价早期免疫干预对预防高危哮喘儿发展为哮喘的意义。方法应用酶联免疫方法测定疫苗干预组、斯奇康干预组及对照组的IFN-γ、IL-2、IL-5、IL-10及IgE水平。结果2y时两干预组的IFN-γ、IL-2水平明显高于对照组(P<0.05),IL-10及IgE水平明显低于对照组(P<0.05),疫苗干预组IL-5明显低于对照组(P<0.05),两干预组之间无明显区别。结论早期两种免疫干预治疗方法对预防高危哮喘儿发展为哮喘有一定作用。

Objective To observe changes of serum IFN-γ.IL and IgE after early immune interference in asthma tendency children in order to evaluate their roles in preventing asthma tendency children form developing asthma. Methods Levels of IFN-γ,IL-2,IL-5,IL-10 and IgE were measured by ELISA in vaccine interference group,SIQIKANG interference group and contrast group. Results At two-year-old,levels of IFN-γ,IL-2 of the two interference groups were higher than that of the contrast group (P<0. 05),while levels of IL-10 and IgE were lower than that of the contrast group (P<0.05),the levels of IL-5 in vaccine interference group was lower than that of the contrast group (P<0. 05),two interference groups had not significant difference (P>0. 05). Conclusion Early immune interference plays a important role in preventing the asthma tendency children form asthma.