9例原发性胃恶性淋巴瘤的临床病理观察

Clinicopathological Study of 9 Cases of Gastric Primary Malignant Lymphoma

目的 :探讨原发性胃恶性淋巴瘤的临床病理特征。方法 :对 1994～ 2 0 0 2年间收治的原发性胃恶性淋巴瘤 9例 ,进行回顾分析。结果 :男 4例 ,女 5例 ,年龄 4 3～ 71岁 (中位年龄 5 3岁 )。临床表现及胃镜检查无特殊 ,多为I～II期的低度恶性肿瘤 ,病程长 ,进展缓慢 ,疗效好。术前活组织检查 :HE染色仅 3例可明确诊断 ,3例曾误诊为低分化腺癌 ;结合免疫组织化学检查 ,7例可术前确诊为恶性淋巴瘤。结论 :胃镜活检 ,HE染色结合免疫组织化学检查 ,可提高胃粘膜相关淋巴组织恶性淋巴瘤的诊断率。

Objective:To study the clinical and pa tho logic features of gastric primary malignant lymphoma. Methods:9 cases of gastric primary malignant lymphoma from 1994 to 2002 were retrospe ctively reviewed.Results: The tumors occurred in 4 men an d 5 women, the age ranged from 43 to 71 years (mean 53 years). None of them had sp ecial clinical and endoscopic findings.Gastrointestinal MALT lymphoma was an in dolent disease that patients had a slow natural course, a high response rate to treatment and a long survival period.By routine HE staining before operation,on ly 3 cases were be diagnosed, 3 other cases were misdiagnosed as poorly differen tiated adenocarcinoma.Combined with immunohistochemistry, 7 of 9 cases were dia gnosed correctly.Conclusion:A combination of endoscopy wi th biopsy,routine HE staining and immunohistochemistry may be of aid to the correc t diagnosis of gastrointestinal MALT lymphoma.