TRAb放射受体分析在甲状腺疾病中的临床应用

Clinical Application of TRAb Radioactive Receptor Assay (RRA) in the Diagnosis of Thyroid Diseases

目的 :探索TRAb放射受体分析在甲状腺疾病中的临床价值。方法 :采用放射受体法 (RRA)对 2 95例 (5组 )甲状腺疾病患者血清中TRAb进行测定 ,测定结果分别与 4 5例正常对照组进行比较。结果 :Graves’病症状未控制组、Graves’病症状控制组及原发性甲减组TRAb均高于正常对照组 (P <0 0 1～ 0 0 0 1) ;而自主性高功能腺瘤组、单纯性甲状腺肿组与正常对照组比较 ,差别无显著性 (P均 >0 0 5 ) ;Graves’病症状未控制组与Graves’病症状控制组比较 ,差别亦无显著性 (P >0 0 5 )。结论 :Graves’病患者和原发性甲减患者的发病可能与TRAb有关 ,TRAb可作为病因诊断的一种指标 ,但不能用来评价Graves’病的甲亢严重程度。

Objective To explore the clinical value of TRAb RRA for the diagnosis and treatment-guide of thyroid diseases. Methods Serum TRAb levels were determined with RRA in 295 patients with various kinds of thyroid diseases (Graves’ disease, uncontrolled 155; Graves’ disease, controlled 80; primary hypothyroidism, 25; autonomous hyperfunctioning adeoma, 15; simple goiter 20) and 45 controls. Results Serum TRAb levels in the patients with Graves’ disease, controlled and uncontrolled, and patients with primary hypothyroidism were significantly higher than those in the controls (P<0.01～P<0.001). However, serum TRAb levels in patients with autonomous hyperfunctioning adenoma and simple goiter were not much different from those in the controls (P>0.05). Also, there was not much difference between levels of TRAb in patients with uncontrolled and controlled Graves’ disease (P>0.05). Conclusion TRAb is possibly involved in the pathogenesis of Graves’ disease and primary hypothyroidism and may serve as an useful diagnostic parameter. However, TRAb levels are not related to the severity of hyperthyroidism.