食管癌患者治疗前后血清TNF,SA和SIL-2R检测的临床意义

Clinical Significance of Measurement of Changes of Serum TNF, Sialic Acid (SA) and Soluble Interlukin-2 Receptor (SIL-2R) Contents After Treatment in Patients with Esophageal Cancer

目的 :探讨食管癌患者治疗前后血清中肿瘤坏死因子 (TNF)、唾液酸 (SA)和白细胞介素 - 2受体(SIL - 2R)含量。方法 :应用放射免疫分析和分光光度计法对 38例食管癌患者进行了治疗前后血清TNF、SA、SIL - 2R含量检测。并以 35名正常健康人作比较。结果 :治疗前食管癌患者血清TNF、SA、SIL - 2R水平均非常显著地高于正常人组 (P <0 .0 1) ,治疗后 2个月则与正常人组比较无显著性差异 (P >0 .0 5 )。结论 :食管癌患者血清中TNF、SA、SIL - 2R含量与该病的发生和发展密切相关。

Objective To explore the changes of serum TNF, SA, SIL-2R contents after treatment in patients with esophageal cancer. Methods Serum contents of TNF (with RIA), SA and SIL-2R (with ELISA) were measured in 38 patients with esophageal cancer both before and after treatment as well as in 35 controls. Results Before treatment, serum levels of TNF, SA and SIL-2R in patients with esophageal cancer were significantly higher than those in the controls (P<0.01). Two months after treatment, these levels dropped markedly to approaching nomal (P>0.05). Conclusion The serum contents of TNF, SA and SIL-2R in patients with esophageal cancer were closely related to the development and progression of the disease process.