三氯乙烯药疹样皮炎患者肝功能与肝纤维化指标变化

Changes of Liver Function and Serum Hepatic Fibrosis Markers Levels in Patients with Trichloroethylene Induced Drugrash-Like Dermatitis

目的 :探讨三氯乙烯药疹样皮炎患者肝功能损害和肝纤维化标志物的变化。方法 :选择 30名三氯乙烯药疹样皮炎患者及 30名健康者作为对照组 ,采用放射免疫分析 (RIA)检测血清透明质酸 (HA)、层粘连蛋白 (LN)、Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (Ⅳ .C)及甘胆酸 (CG)水平 ;化学法显色测定血清单胺氧化酶 (MAO) ;全自动生化仪测定转氨酶 (ALT)、转酞酶 (GGT)、总蛋白 (TP)、白蛋白 (Alb)胆汁酸 (TBA)等肝功能变化指标 ;分析各项指标的相关性。结果 :三氯乙烯药疹样皮炎患者各项肝功能指标变化明显 ;肝纤维化指标MAO、HA、PCⅢ、Ⅳ、CG水平明显增高 (P <0 0 1) ,与ALT、GGT、TP、Alb有良好的相关性。结论 :三氯乙烯药疹样皮炎患者早期肝脏损害严重并伴有肝脏纤维化现象。

Objective To investigate the liver function damage and serum hepatic fibrosis markers levels changes in patients suffering from trichloroethlylene induced drugrash-like dermatitis. Methods Serum hyaluronic acid (HA), lamine (LN), procollagen typeⅢ (PCⅢ), type Ⅳ collagen (ⅣC) levels (with RIA), mono-amine oxidase (MAO) activity (with chemo-colorimetry) and liver function tests (including ALT, AGT, total protein, albumin, total bile acid, with automated biochemical analysis system) were determined in 30 controls and 30 patients with trichloroethylene induced drugrash-like dermatitis. Results Severe liver function damage was demonstrated in all the patients. The serum hepatic fibrosis markers levels were singificantly increased (vs controls, P<0.01) and correlated well with the degree of hepatic damage. Conclusion Liver damage occurred early in patients with trichloroethylene induced dermatitis, accompanied with laboratory evidence of hepatic fibrosis.