脑卒中患者血清脂蛋白(a)的变化及临床意义

Clinical Significance of Changes of Serum Lipoprotein(a) Levels in Patients with Cerebral Vascular Accidents

目的 :探讨脑卒中患者血清脂蛋白 (a) [LP(a) ]含量的变化 ,以阐明LP(a)与脑卒中的关系及作用机制。方法 :采用酶联免疫吸附试验 (ELISA)双抗体夹心法检测 10 0例患者和 6 0例正常对照LP(a)的含量。结果 :脑卒中组LP(a)水平高于对照组 (P <0 0 1)。脑卒中合并糖尿病患者LP(a)水平明显高于不合并糖尿病患者 (P <0 0 1)。结论 :LP(a)是脑卒中患者相对独立的危险因素 ,它的水平可作为判断脑卒中患者的预后指标之一。

Objective To investigate the relationship between changes of serum lipoprotein(a) levels and development of stroke. Methods Lipoprotein(a) levels were determined with ELISA in 100 patients with stroke and 60 controls. Results The serum LP(a) levels in patients with stroke complicated with diabetes were also significantly higher than those in patients with stroke but without diabetes (P<0.01). Conclusion The levels of serum LP(a) was a relatively independent risk factor, and it could be of some prognostic value.