糖尿病对充血性心力衰竭患者心率变异性的影响

Effect of Diabetes Mellitus on Heart Rate Variability in Patients with Congestive Heart Failure

目的 :观察糖尿病是否会加重充血性心力衰竭 (CHF)患者的自主神经功能异常。方法 :对 35例糖尿病合并CHF和 4 5例非糖尿病CHF患者行 2 4h动态心电图检查 ,采用 2 4h时域和频域心率变异性方法来评价自主神经功能。结果 :两组有重要预后价值的HRV指标 (SDNN ,SDANN5及TP功率 )无差别。反映迷走神经活性的HRV指标 (pNN5 0 ,RMSSD及HF功率 )在两组有类似程度的降低。糖尿病组的LF明显低于非糖尿病组[(3.6 1± 0 .18)vs (4.0 9± 0 .2 1)In ms2 ,P =0 .0 4 ]。合并糖尿病组患者的LF/HF也明显低于非糖尿病组 [(2 .2± 0 .2 )vs (1.4± 0 .2 ) ,P =0 .0 0 1]。结论 :在CHF患者 ,合并的糖尿病不影响具有预后价值的HRV指标。此外 ,在CHF交感神经刺激增加的情况下 ,糖尿病不进一步降低迷走神经活性 ,但降低交感神经活性。

Objective:To determine if the severity of autonomic dysfunction in patients with chronic heart failure (CHF) are affected by the presence of diabetes. Methods: Holter ECGs from 35 diabetic patients and 45 nondiabetic controls with CHF were analyzed. The severity of autonomic dysfunction was assessed using 24-hour time- and frequency-domain HRV analysis. Results: Prognostically important HRV measures (SDNN, SDANN5, and total power) were not different between the two groups. Time- and frequency-domain parameters modulated by parasympathetic tone (pNN50, RMSSD, and HF power) were depressed to a similar degree in the diabetic and the nondiabetic groups. The low frequency power was significantly lower in diabetic patients [(3.61±0.18)vs (4.09±0 21) In-ms2,P=0.04]. The ratio of low to high frequency power was substantially lower in the diabetic group [(2 2±0.2) vs (1.4±0.2), P=0.001]. Conclusion: In the presence of CHF, HRV parameters that are most predictive of adverse outcome are similar in diabetic and nondiabetic patients. Furthermore, during increased sympathetic stimulation in the setting of heart failure, diabetes does not worsen parasympathetic withdrawal but may mitigate sympathetic activation.