转化生长因子β及其信号转导与相关细胞增殖研究进展
摘要
转化生长因子β(transforming growth factor-β,TGF-β)在哺乳动物细胞中有4种异构型即TGF-β1-4,均有112个氨基酸组成,分子量均为12.5KD,以纯二聚体形式存在.目前研究较多的是TGF-β1.
出处
《新疆医学》
2004年第6期138-141,共4页
Xinjiang Medical Journal
参考文献19
-
1Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, andheritable disorders.Cell. 2000,103(2) :295 -309.
-
2Hajnal A. Fine - tuning the RAS signaling pathway: Zn2 +makes the difference. Mol Cell. 2002,9 (5) :927 - 928.
-
3Mann DJ, Higgins T, Jones NC, et al. Differential control of cyclins D1 and D3 and CDK inhibitor p27 by diverse signaling pathways in Swiss 3T3 cells. Oncogene. 1997; 14:1759 -1766.
-
4Ortega S, Malumbres M, Barbacid M. Cyclin D - dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta.2002,1602(1) :73- 87.
-
5Xiaotang Hu, Kenneth S, Zuckerman. Transforming growth factor:signal transduction pathways, cell cycle mediation, and effects on hematopoiesis. J of Hematotherapy and Stem Cell.Research. 2001,10: 67 - 74.
-
6Sumudra P. Repression of transforming growth factoβreceptor type 1 promoter expression by 3p1 deficiency. Oncogene.2000,19:4660 - 4667.
-
7Wakefield LM, Roberts AB. TGF - Beta signaling: positive and negative effects on tumorigenesis. Current opinion in genetics and development. 2002,12 (1) : 22 - 29.
-
8Seoane J, Pouponnot C,Staller P. TGFβinfluences myc, Miz-1 and smad to control the CDK inhibitor p15ink4b. Nature cell biology. 2001,3(4) :400 - 408.
-
9Majesky MW,Lindner V,T wardzik DR,et al. Production of transforming growth factor betal during repair of arterial injury. J Clin Invest. 1991,88(3) :904 - 910.
-
10Nikol S, Isner JW,Pickering JG, et al. Expression of J transforming growth factor betal is increased in human vascular restenosis lesions.J Clin Invest. 1992,90(4) :1582 - 1592.
-
1肌肉生理学[J].国外科技资料目录(医药卫生),2000(7):9-9.
-
2许瑚.载脂蛋白E4水平与阿尔采默病关系的分析[J].中国现代医药杂志,2011,13(10):99-99. 被引量:1
-
3杜丽蕊,何贤辉.PKCθ在T细胞活化和IL-2表达中的作用[J].国外医学(免疫学分册),2004,27(6):346-350. 被引量:2
-
4张振华(摘).08057 Ampligen和Alferon治疗禽流感坚实的数据[J].国外药讯,2006(8):29-29.
-
5倪以亮,陈晨,任晓莉,吴高义,丁凤,陈磊.慢性睡眠剥夺致大鼠咬肌肌球重链蛋白异构型改建[J].中华行为医学与脑科学杂志,2016,25(3):204-209.
-
6李旭,申乐,许力,刘薇,虞雪融,黄宇光.突触后致密物蛋白质95基因沉默及对神经病理性疼痛大鼠疼痛行为的干预[J].协和医学杂志,2011,2(4):343-349. 被引量:6