期刊文献+

转化生长因子β及其信号转导与相关细胞增殖研究进展

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摘要 转化生长因子β(transforming growth factor-β,TGF-β)在哺乳动物细胞中有4种异构型即TGF-β1-4,均有112个氨基酸组成,分子量均为12.5KD,以纯二聚体形式存在.目前研究较多的是TGF-β1.
出处 《新疆医学》 2004年第6期138-141,共4页 Xinjiang Medical Journal
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  • 1Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, andheritable disorders.Cell. 2000,103(2) :295 -309.
  • 2Hajnal A. Fine - tuning the RAS signaling pathway: Zn2 +makes the difference. Mol Cell. 2002,9 (5) :927 - 928.
  • 3Mann DJ, Higgins T, Jones NC, et al. Differential control of cyclins D1 and D3 and CDK inhibitor p27 by diverse signaling pathways in Swiss 3T3 cells. Oncogene. 1997; 14:1759 -1766.
  • 4Ortega S, Malumbres M, Barbacid M. Cyclin D - dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta.2002,1602(1) :73- 87.
  • 5Xiaotang Hu, Kenneth S, Zuckerman. Transforming growth factor:signal transduction pathways, cell cycle mediation, and effects on hematopoiesis. J of Hematotherapy and Stem Cell.Research. 2001,10: 67 - 74.
  • 6Sumudra P. Repression of transforming growth factoβreceptor type 1 promoter expression by 3p1 deficiency. Oncogene.2000,19:4660 - 4667.
  • 7Wakefield LM, Roberts AB. TGF - Beta signaling: positive and negative effects on tumorigenesis. Current opinion in genetics and development. 2002,12 (1) : 22 - 29.
  • 8Seoane J, Pouponnot C,Staller P. TGFβinfluences myc, Miz-1 and smad to control the CDK inhibitor p15ink4b. Nature cell biology. 2001,3(4) :400 - 408.
  • 9Majesky MW,Lindner V,T wardzik DR,et al. Production of transforming growth factor betal during repair of arterial injury. J Clin Invest. 1991,88(3) :904 - 910.
  • 10Nikol S, Isner JW,Pickering JG, et al. Expression of J transforming growth factor betal is increased in human vascular restenosis lesions.J Clin Invest. 1992,90(4) :1582 - 1592.

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