1Beck- Nielsen H, Groop LC. Metabolic and genetical characterization of prediabetic states. J Clin Invest, 1994,94:1714 -1721.
2Boden G. Fatty adds and insulin resistance. Diabetes Care,1996,19:394 - 395.
3Zarjevski N, Cusin I, Vettor R, et al. Chronic intracerebroventricular neuropeptide Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology, 1993,133:1753 - 1758.
4Billington CJ, Briggs JE, Harker S, et al. Neuropenptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am J Physiol 1994,266: R1765 - R1770.
5Hennes MI, Dua A, Kissehah AH. Effects of free fatty acids and glucose on splanchnic insulin dynamics. Diabetes, 1997,46: 57 - 62.
7Zhou YP, Berggren PO, Grill VE. A fatty acid - induced decrease in pyruvate dehydrogenase activity is an important determinant of B cell dysfunction in obese diabetic db/db mouse.Diabetes, 1996,45: 580 - 586.
8Shimabukuro M, Zhou YT, Levi M, et al. Fatty acids induced B cell apoptosis:a link between obesity and diabetes. Proc Nail Acad Sci USA, 1998,95: 2498 - 2502.
9Zumsteg U,Frigerio S,Hollander GA. Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine- induced murine β- cell damage. Diabetes,2000,49:39-47.
10Nakata M, Uto N, Maruyama I, et al. Nitric oxide induces apoptosis via Ca^2+ -dependent processes in the pancreatic beta- cell line MIN6. Cell Strut Funct, 1999,24:451 - 455.