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大鼠同种异体肾移植实验模型的研究现状

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摘要 动物肾移植模型被广泛用于器官保存及免疫等相关研究.目前已有多种动物模型用于实验研究,如猪、狗、兔、大鼠及小鼠等[1-5].其中以大鼠模型最为常用.其优点有:1.动物来源多,经济;2.饲养简单;3.移植手术的无菌要求较大动物要小;4.应用近交系大鼠可在术后不用免疫抑制剂,自体移植器官能够长期存活;5.血管和输尿管的直径满足吻合的要求.缺点是手术难度大,成功率不高,要求实验者具有一定的显微外科技术基础.为提高大鼠肾移植成功率,在回顾近年此方面文献的基础上,本文就建立大鼠肾移植模型过程中有关问题进行简要回顾.
作者 李素华 刘健
出处 《新疆医学》 2004年第6期148-151,共4页 Xinjiang Medical Journal
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参考文献40

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