盆底支持结构电刺激治疗膀胱过度活动症的临床效果观察

A clinical study of pelvic floor electrical stimulation in treatment of overactive bladder

目的 观察盆底支持结构电刺激疗法对膀胱过度活动症 (overactivebladder,OAB)的治疗效果。方法 将临床及尿动力学检查确诊的 6 0例OAB患者 ,随机分为行电刺激治疗 (电刺激组 ) 35例 ,及药物治疗 (药物组 ) 2 5例。电刺激组 ,采用盆腔生物反馈电刺激治疗仪 ,通过阴道或直肠电极 ,对患者阴道或直肠内进行 2 0～ 30次 8～ 70mA的电刺激治疗 ;药物治疗组 ,采用酒石酸托特罗定 2mg口服 ,每天 2次 ,共 2～ 4周。结果 电刺激组的治愈率为 37% (13/35 ) ,总有效率为 74 % (2 6 /35 ) ,满意率为 83% (2 9/35 ) ;药物组的治愈率为 4 0 % (10 /2 5 ) ,总有效率为 76 % (19/2 5 ) ,满意率为 80 % (2 0 /2 5 ) ,两组疗效及满意率比较 ,差异无显著性 (P >0 0 5 )。两组的副作用比较 ,差异有显著性 (P <0 0 5 )。结论 盆底支持结构电刺激疗法能有效治疗OAB ,但长期疗效仍需进一步观察。

Objective To observe the efficacy of electrical stimulation in treatment of overactive bladder (OAB) Methods Patients( n =60)with overactive bladder were randomly divided into 2 groups Electrical stimulation group ( n =35) used an instrument for electrical stimulation through a special vagina or rectum probe transfer current (8 70 mA), for 20 min,qd, for 20 30 times Medical group ( n =25) received oral tolterodine 2 mg, bid, for 2 4 weeks Results The total effective rate and cure rate were 74%, 37% in electrical stimulation group and 76%, 40% in medical group, respectively, showing no significant difference between two groups( P >0 05) While patients′ satisfactory rate was significantly higher in electrical stimulation group than in medical group( P <0 05) Side effects were more commonly seen with tolterodine Conclusions Electrical nerve stimulation is effective and safe for overactive bladder Further studies are needed to show the long term efficacy and cost effectiveness