摘要
将60只雄性艾维茵商品代肉鸡常规育雏,17日龄随机分为3组:常温对照组(常温组)、低温模型组(低温组)和低温扎鲁司特组(扎鲁司特组)。各组于处理后14 d(31 日龄)和 21 d(38 日龄)分别用右心导管法及直接导管法测定扎鲁司特对肺动脉压(PAP)和股动脉压(FAP)的影响,同时测定红细胞压积(PCV)和腹水心脏指数(AHI)。结果:(1)在低温环境的早期,扎鲁司特使肉鸡肺动脉收缩压和舒张压均升高,后期仅使舒张压升高;(2)扎鲁司特使PCV升高,增加了血液黏性阻力;(3)扎鲁司特使AHI升高,促进右心肥大;(4)扎鲁司特对股动脉压无显著性影响。可见扎鲁司特促进了肉鸡肺动脉高压综合征的发生发展。
The effect of Zafirlukast on pulmonary hypertension (PH) induced by low ambient temperature in broiler chickens was investigated. Sixty male 17-day-old broiler chickens were randomly divided into three groups: normal ambient temperature group (NT,22~23 ℃), low ambient temperature group (LT, 9~11 ℃) and Zafirlukast group in low ambient temperature (ZLT, 9~11 ℃). At 31, 38 days of age, 7 birds were randomly taken from each group for measuring the pulmonary artery pressure by right cardiac catheter and femoral artery pressure (FAP) by directly measured methods. The ascites heart index (right ventricular weight/total heart weight,AHI) and the packed cell volume (PCV) was measured too. The results showed: (1) At 31 days of age, the pulmonary artery systolic pressure of ZLT was significantly higher than that of LT and NT(P<0.05), and at 38 days the pulmonary artery diastolic pressure of ZLT was significantly higher than that of NT (P<0.05). (2) The PCV of ZLT was significantly greater than that of LT (P<0.05) at 31,38 days. (3) The AHI of ZLT was significantly greater than that of LT (P<0.05) at 31 days. (4) The FAP of all groups were not significantly different (P>0.05). These data indicate that Zafirlukast promote the development of PHS induced by low ambient temperature in broiler chickens.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2005年第2期191-194,共4页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金项目(30070567
30371063)
