脑梗死和心肌梗死患者血栓调节蛋白的检测及临床应用

Study on the detection and application of the level of the thrombomodulin in myocardial infarction and cerebral infarction

目的 研究血浆血栓调节蛋白(TM)水平与心脑、血管内皮细胞损伤和血栓形成的关系。方法 采用 定量酶联免疫吸附试验(ELISA)检测了30例心肌梗死患者、45例脑梗死患者和20名健康人TM的含量。结果 心肌梗死组及脑梗死组TM水平显著高于对照组(P均<0.01)。结论 TM作为新的血管内皮损伤的分子标 志物对临床有重要价值。

Objective To study the relationship between the level of thrombomodulin (TM) and the injury of endothelial cells and the formation of thrombosis. Methods The level of TM in 30 myocardial infarction (MI) patients, 45 cerebral infarction (CI) patients and 20 healthy controls was detected by ELISA. Results The level of TM in MI and CI was significantly higher than that in controls (P<0.01). Conclusions TM can be used as a new molecular marker to detect the injury of endothelial cells.