阿魏酸钠对原发性高血压患者口服甲巯丙脯酸的降压效果及尿中TXA_2排泄的影响

The Influence of Sodium Ferulate on Hypotensive Effect and Urinary Excretion of TXB_2 after Captopril in Essential Hypertensive Patients

将原发性高血压患者44例随机分为两组,观察单独口服甲巯丙脯酸(CAP)和 CAP 与阿魏酸钠(SF)联合服用后肱动脉血压、尿中 TXB_2浓度及血中血管紧张素转化酶(ACE)活性的变化。结果表明,CAP 使原发性高血压患者血中 ACE 活性减低,有显著降压作用。但尿中 TXB_2排泄增加;SF 无降压作用,与 CAP 联合应用可使原发性高血压患者服用 CAP 后尿中 TXB_2排泄增加受到抑制,降压作用得到加强。

Angiotensin converting enzyme(ACE)inhibitor,Captapril(CAP),is a potent antihy- pertensive agent.Some reports suggest that CAP stimulates TXA_2 synthesis in the patients with essential hypertension.Sodium ferulate(SF)inhibits TXA_2 synthesis.In present study, the influence of SF on hypotensive effect and urinary exceretion of TXB_2(a stable metabolite of TXA_2)after CAP was observed in 44 patients with essential hypertension.A single oral dose of CAP(50 mg)decreased mean arterial pressure (from 16.25+0.85 to 13.65+1.1.14 kPa,n=28,P<0.01)and increased urinary TXB_2 excretion significantly(from 119.12+ 57.12 to 183.32+78.61 pg/min,n=16,P<0.05).The administration of SF 300 mg/day for one day did not affect the mean arterial pressure.CAP in combination with SF induced a decrease both in mean arterial pressure(from 16.33+1.14 to 13.83+1.77 kPa,n=16,P< 0.01)and urinary TXB_2 excretion(from 155.89+69.64 to 133.43+60.01 pg/min,n=16, P>0.05),though the latter was not so significant.Compared with the administration of CAP alone,the combination of CAP and SF induced stronger hypotensive effect(P<0.05) and the increased urinary TXB_2 excretion could be inhibited by SF.But the inhibition to ACE was the same.These results suggested that the increased urinary TXB_2 excretion by CAP can be inhibited and the hypotensive effect of CAP is potentiated by SF in essential hy- pertensive patients.