脑内不同部位颈交感神经节移植后大鼠旋转行为改善的观察

Recovery of Rotational Behavior After SCG Transplantaton in 6-OHDA-Induced Parkinson Model Rat

大鼠脑内黑质注入六羟基多巴(6-OHDA).使其成为帕金森病的模型后.将大鼠自体颈交感神经节移植入脑内不同部位,以观察其对模型的旋转行为的纠正程度.我们选择了两处移植靶点(尾状核和壳核)进行实验.结果表明颈交感神经节在两处移植点具有相似的效应,均可使模型鼠在注入阿仆吗啡后的单方向旋转强度下降约50%。儿茶酚胺组织荧光检查显示被移植的神经节成活良好.

Autologous superior cervical ganglion transplantation was performed into the different places in rat's brain where the nigro-striatal dopamine system was unilaterally destoried by 6-OHDA injection.Two different locations for grafts were tested,namely the caudate and the putament.Almost the same effect on recovering ratationlal behaviour induced by apo- morphine was acheived in both groups.The intensity of ratation was about 50 per cent de- crease afer grafting.Catecholamine fluroscence histoehemical study showed good survival of grafted tissue.