阿莫西林、舒巴坦联用对鸭实验性大肠杆菌病的疗效试验

Efficacy of Amoxicillin/Sulbactam in the Treatment of Experimentally Induced E.coli Infection in Ducks

用试管两倍稀释法测定了阿莫西林、阿莫西林与舒巴坦联合对大肠杆菌的体外抗菌活性,并观察阿莫西林与舒巴坦联合治疗耐阿莫西林大肠杆菌诱发的鸭大肠杆菌病的效果。结果表明:阿莫西林与舒巴坦联合对鸭大肠杆菌产酶菌株体外抗菌活性优于阿莫西林,表现为明显的体外协同作用。阿莫西林与舒巴坦联用治疗耐阿莫西林大肠杆菌诱发的鸭大肠杆菌病,按10mg/kg体重(以阿莫西林量计算)肌肉注射,阿莫西林与舒巴坦联用1∶1和2∶1的有效率、治愈率分别为92.5%、92.5%和85%、80%,均显著高于感染对照组、阿莫西林饮水组及阿莫西林肌肉注射组(P<0.01)。

In vitro antibacterial activities of amoxicillin and amoxicillin pl us sulbactam against E.coli were evaluated with the method of broth two-fold dil ution,and efficacy of amoxicillin plus sulbactam in the treatment of experimenta lly induced β-lactamase-producing E.coli infection in ducks was studied. Result s showed that in vitro antibacterial activitiy of amoxicillin plus sulbactam aga inst β-lactamase-producing E.coli in ducks was much better in comparison with a moxicillin alone.In the treatment of duck colibacillosis,combination of amoxicil lin with sulbactam at the ratio of 1∶1 and 2∶1 was administered intramuscularl y at a dose of 10mg/kg (based on amoxicillin) twice daily for 4 days, their effi cacious rate was 92.5%,85%,respectively and their curative rate was 92.5%,80%,re spectively,All of above were significantly higher than that of amoxicillin alone (P<0.01=.