急慢性肝炎、肝硬化病人血清一氧化氮水平及其变化规律的临床研究

A Clinical Study on NO Level and Change Rule of Serum in Patients with Virus Hepatitis and Cirrhosis

目的 研究病毒性肝炎和肝硬化病人血清一氧化氮 (NO)水平的动态变化规律。方法 对 15 2例各型病毒性肝炎和肝硬化病人的血清NO水平进行检测 ,并与不同病程、血清白蛋白、肝纤维化指标和Child-Pugh分级等进行对照研究。结果 (1)各组肝炎和肝硬化病人NO浓度与正常对照组间差异均有显著性意义。 (2 )在各组肝炎和肝硬化的病情活动期 ,血清NO升高 ,而随着病情的逐渐恢复 ,血清NO的浓度逐渐下降 (P <0 0 1)。 (3)肝硬化低白蛋白血症组病人血清NO的浓度与正常白蛋白组差异有显著性意义 (P <0 0 1)。 (4 )肝硬化病人肝脏储备功能越差 ,血清NO浓度越高 ,Child -Pugh分级A、B、C三组比较差异有显著性意义。 (5 )肝硬化腹水组病人血清NO浓度较无腹水组差异有显著性意义 (P <0 0 1)。 (6 )慢性肝炎和肝硬化病人肝纤维化血清学标志物HA、LN、IV -C、PCⅢ升高的病人血清NO的含量与未升高组间差异有显著性意义。结论 急慢性肝炎和肝硬化时血清NO浓度的变化与肝内炎症程度。

Objective To study the change rule of serum NO level in patients with virus hepatitis and cirrhosis.Methods Serum NO was detected in 152 cases of virus hepatitis and cirrhosis, its regular change was analyzed and was compared with the different disease course, serum albumin, hepatic fibrosis mark and Child-Pugh.Results (1) Serum concentration of NO was significantly different in virus hepatitis and cirrhosis group from that of the control group. (2) Serum concentration of NO was higher in the active phase of illness, it was less after the convalescent period of illness (P<0.01). (3) Serum concentration of NO was higher than normal range group of serum albumin on lower range group of serum albumin (t=9.41,P<0.01). (4) Serum concentration of NO was the highest in the C group of the Child-Pugh.(5)Serum concentration of NO on ascites group of cirrhosis was higher than non-ascites group (t=10.82,P<0.01). (6) Among the patients with the raised HA, LN, IV-C and PCⅢ, serum concentration of NO was higher.Conclusion Serum concentration change of NO was relative with hepatic inflammation, severe degree of hepatitis and clinical development in virus hepatitis and cirrhosis.