摘要
以对氟苯酚为起始原料合成了6-氟-4-色满酮-2-羧酸,该中间体经催化还原获得了消旋的6-氟-色满-2-羧酸.化学拆分该消旋体和D-(+)-α-苯乙胺及L-(-)-α-苯乙胺形成的非对映体盐,分别得到了(R)-及(S)-6-氟-色满-2-羧酸.
6-Fluoro-4-chromanone-2-carboxylic acid and 6-fluorochroman-2-carboxylic acid were both synthesized from p-fluorophenol. The (R)- and (S)-6-fluorochroman-2-carboxylic acids were obtained by formation of theirs salts with optical active (R)-(+)- or (S)-(-)-alpha-methylbenzylamine, respectively.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2005年第2期201-203,共3页
Chinese Journal of Organic Chemistry
基金
国家863计划(No.2003AA323030)
国家自然科学基金(No.50272069)资助项目.