单纯性肥胖男生血清瘦素、性激素水平及性发育调查

Research of serum leptin, sexual hormones, and sexual development in male students with simple obesity

目的:研究男性血清瘦素水平与单纯性肥胖、青春期性发育的关系.方法:49名8～16岁单纯性肥胖男生和44名正常男生按年龄划分为8～岁、11～岁和14～16岁3个年龄段,采用放射免疫法对各组男生进行血清瘦素、睾酮、雌二醇含量定量测定,同时进行首次遗精时间调查.结果:肥胖组各年龄段血清瘦素水平均高于正常组(P＜0.05或0.01);随着年龄增长,肥胖组男生血清瘦素水平呈现先上升后下降的变化趋势,在11～岁年龄段达最高值;而正常组男生血清瘦素水平随着年龄增长则呈现下降的趋势.肥胖组男生首次遗精时间(12.5±1.2)岁,早于正常组男生(13.2±1.2)岁(P＜0.01).雌二醇水平在11～岁年龄段,肥胖组低于正常组(P＜0.05).睾酮水平各年龄段,肥胖组与正常组比较,差异均无统计学意义(P＞0.05).肥胖组男生睾酮与瘦素呈负相关(r=-0.33,P＜0.05).结论:单纯性肥胖男生血清瘦素水平偏高;持续高浓度的瘦素水平可能对男性性发育产生一定的负面影响.

Aim: To research the relationship between serum leptin and sexual development in male students with simple obesity. Methods: Serum leptin, testosterone, and estradiol levels in 49 male students with simple obesity and 44 normal male students was detected with quantitative examination. At the same time, the first spermatorrhea time was investigated.The obesity and the normal students were divided into 3 groups according to the age: 8~years, 11~years, 14~16 years,respectively.Results: Serum leptin in different age groups of students with obesity was significantly higher than that of the normal students(P<0.01 or 0.05). With the increase of age, serum leptin in the students with obesity went up firstly,and reached peak at age of 11~years,then went down. The serum leptin in the normal students went down continuously with the increase of age. The first spermatorrhea time((12.5±1.2) years) of students with obesity was earlier than that of the normal students (13.2±1.2) years(P<0.01).Serum estradiolum in students with obesity aging 11~years was significantly lower than that of the normal students(P<0.05). No significant difference was found in testosterone level between the two groups.Serum testosterone was negatively correlated with serum leptin in the students with obesity (r= -0.33,P<0.05). Conclusion: The higher level of serum leptin may affect the sex maturation for male students with simple obesity.