自体外周血CD34+细胞移植治疗系统性红斑狼疮的护理

Nursing care of systemic lupus erythematosus treated by autologous peripheral CD34+ transplantation

对11例系统性红斑狼疮患者进行了自体外周血CD34^+细胞移植治疗,患者合并相关并发症22例次,除1例移植后3月合并肺部感染死亡,其他病情均缓解,取得了良好疗效。由于患者移植前已经合并多脏器功能损害,因此在动员及移植期间应密切观察心、肾功能的变化,如尿量、尿色、中心静脉压等,移植后期注意病毒、真菌、结核杆菌感染的发生,及早发现可提高治疗效果。

cases of systemic lupus erythematosus (SLE) were treated using autologous peripheral CD34+ transplantation, combined with 22 complications. All achieved affirmative curative effect but one died from combined pulmonic infection 3 months after transplantation. Since multi-organ-dysfunctions common before transplantation, we should close observe the changes in cardiac and renal functions such as urinary volume, urinary color and central venous pressure before and during transplantation and attach importance to the infections by virus, fungi and tuberculosis after transplantation so as to find them early and thus increase the curative effect.