摘要
对血管紧张素 (1- 7)的研究使我们对肾素 -血管紧张素系统 (RAS)有了更全面的认识。血管紧张素 (1-7)通过特异性的受体发挥生理作用。血管紧张素Ⅰ和血管紧张素Ⅱ经过特异的肽链内切酶变为血管紧张素 (1 -7) ,再经血管紧张素转换酶作用降解为无活性的血管紧张素 (1- 5 )。血管紧张素 (1- 7)具有抗增殖、扩张血管、抗氧化应激及促进纤溶的作用。
The recognition of rennin-angiotensin system (RAS) has been developed as the studies of angiotensin(1-7), a new member of RAS. Angiotensin(1-7) plays its physiological roles through a specific receptor. Angiotensin(1-7) was produced from angiotensinⅠ and angiotensin Ⅱ by tissue peptidases, including neutral endopeptidase (neprilysin), thimet oligopeptidase, prolyl-carboxypeptidase, and prolyl-endopeptidase. And then angiotensin(1-7) was degenerated by angiotensin converting enzyme. Angiotensin(1-7)has the effects of vasodilation and anti-proliferation.
出处
《中国心血管杂志》
2005年第1期60-62,共3页
Chinese Journal of Cardiovascular Medicine
