肾素血管紧张素系统基因多态性与高血压及血管紧张素转换酶抑制剂的降压疗效的关系

Relationship between gene polymorphism on renin angiotension system and essential hypertension and effect of angiotension converting enzyme inhibitor.

高血压病是一种环境与遗传因素相互作用的疾病 ,它是冠心病、脑卒中、左心室肥厚、急性心肌梗死等心血管疾病的独立危险因素 ,寻找其相关及致病基因为近年研究的热点 ,特别是肾素血管紧张素系统基因的多态性与高血压的相互关系成为分子生物学研究的热点。这些研究表明高血压可能是基因与基因、基因与环境共同作用的结果。在高血压的治疗中个体对血管紧张素转换酶抑制剂类药物降压疗效的反应存在着差异 ,遗传因素决定了部分差异。

Essential hypertension is an interactional disease influenced by environment and generation, and it is also an independent risk factor for cardiovascular diseases such as coronary atherosclerotic heart disease, left ventricular hypertrophy, and acute myocardial infarction etc. To find the correlated nosogenetic genes became the focus in research fields recently. These researches demonstrate that essential hypertension maybe the co-operated results of gene to gene, and gene to environment. At the same time, there exists the distinguished differences on the individual effect when using angiotension converting enzyme inhibitor to treat essential hypertension, and the genic factor results in those differences.