急性心肌梗死和心房纤维性颤动患者CD62P、CD63与vWF检测的意义

The significance on examination of CD62P、CD63 and vWF in patients with acute myocardial in-farction or atrial fibrillation

目的 探讨急性心肌梗死(AMI)和心房纤维性颤动(AF)患者血小板膜糖蛋白CD62P、CD63与vWF 临床检测的意义。方法 采用流式细胞技术和夹心酶免疫吸附试验检测AMI和AF患者CD63、CD62P和vWF 的变化。结果 AMI和AF患者的CD62P分别为11.29％和8.72％、CD63分别为8.72％和2.66％,明显高于对 照组(3.37％和1.32％),AMI组的vWF为167.83％,明显高于对照组(102.71％),AF组为117.05％,与对照组比 较无显著性差异。 结论 急性心肌梗死和心房纤维性颤动患者CD62P和CD63的表达水平明显增高,进一步证 实CD62P和CD63为血栓形成的血小板活性物质,参与血栓性疾病的促凝血作用。

Objective To investigate the significance on examination of CD62P,CD63 and vWF in patients with a-cute myocardial infarction ( AMI) or atrial fibrillation ( AF). Methods By flow cytometry for CD62P and CD63 and by ELISA for vWf were examined in 38 cases with AMI or AF. Results In AMI cases and AF cases,the expression of platelet membrane glycoprotein CD62P was 11. 29% and 8. 72% ; CD63 was 8. 72% and 2. 66% , vWF was 167. 83% and 117. 05% respectively,those were obviously higher than normal control(3. 37%、1. 32% and 102. 71% respectively). But vWF in AF group was no difference in contrast with control. Conclusion The level of expression of CD62P and CD63 in cases with acute myocardial infarction and atrial fibrillation were elevated,it showed that the platelet could be an activation in thrombosis, and as the pro-coagulant activity took part in thrombotic diseases.