异环磷酰胺和Vp-16治疗小细胞肺癌疗效观察

Efficacy of ifosfamide and Vp-16 in chemotherapy of 41 cases of small cell undifferentiated lung cancer

目的 观察异环磷酰胺、Vp 16联合化疗治疗小细胞未分化肺癌的疗效 ,探讨其副作用及影响预后的因素。方法 采用异环磷酰胺、Vp 16对 4 1例小细胞未分化肺癌进行化疗 ,Mesna、生理盐水水化。结果 完全缓解 (CR) 2 8例 ,占 6 8.3% ;部分缓解 (PR) 10例 ,占 2 4 .4 % ;进展 (PD) 3例 ,占7.3% ,总有效率为 92 .7%。 2例生存 5年 ,5例生存 3年以上。 13例出现不同程度的骨髓抑制 ,2例肾功损害 ,3例肝功损害 ,经间歇期及对症治疗均恢复正常。结论 异环磷酰胺、Vp 16联合化疗符合小细胞未分化肺癌治疗应大剂量、联合用药的特点 ,化疗效果好 ,毒副作用轻。

Objective To observe the efficacy of ifosfamide and Vp-16 in chemotherapy of small cell undifferentiated lung cancer,and investigate the adverse effect and factors affecting the prognosis.Methods Forty-one cases of small cell undifferentiated lung cancer received chemotherapy with ifosfamide and Vp-16, hydration by Mesna and normal saline.Results Complete remission (CR) was found in 28 cases (68.3%) and partial remission (PR) in 10 (24.4%), with the total remission rate of 92.7% (38/41), progression of disease (PD) in 3 cases (7.3%). Two patient survived for more than 5 years, 5 cases over 3 years.Different levels of bone marrow suppression were observed in 13 cases,renal damage in 2 cases,hepatic damage in 3 cases, whose functions were restored to normal after the interval period and symptomatic therapy.Conclusion Chemotherapy with the combination of ifosfamide and Vp-16 is in accordance with the need of large dose and combined use of chemicals for small cell undifferentiated lung cancer and showed satisfactory results and mild adverse effect.