摘要
目的 观察不同剂量伊班膦酸钠对骨转移疼痛的治疗效果。方法 76例恶性肿瘤骨转移患者随机分为A、B、C组 ,4周为一疗程 ,每疗程药量A组 2mg ,B组 4mg ,C组 6mg ,共 3个疗程。分别于用药后第 4 ,8,12周评价疗效。结果 治疗后 4周评价疗效 ,C组与A、B组差异有显著性 (P <0 .0 0 5 ,P <0 .0 5 ) ,A、B组比较差异无显著性 (P >0 .0 5 )。用药第 1周内 ,A、B、C三组中口服止痛药减少患者分别为 1,3,6例。治疗后 8周评价 ,B、C组与A组差异有显著性 (P <0 .0 5 ,P <0 .0 0 5 ) ,B、C组之间差异无显著性 (P >0 .0 5 )。治疗后 12周评价 ,A、B、C三组有效率分别为 6 1.5 %、88.0 %和92 .0 %。结论 高剂量伊班膦酸钠治疗骨转移疼痛 ,缓解更快、更持久 ,疗效更好。
Objective To observe the efficacy of different dosages of sodium ibandronate in treatment of bone metastasis pain.Methods Seventy six patients with malignant bone metastasis were randomly divided into 3 groups A,B and C.Four weeks constituted one treatment course,during which group A was given 2mg,group B 4 mg and group C 6 mg,and a total of 3 treatment courses were given.Evaluation was conducted after 4,8 and 12 weeks.Results Evaluation at 4 weeks found obvious difference between group C and groups A and B( P <0.005, P <0.05),but no obvious difference was seen between groups A and B( P >0.05).Within the first week,the numbers of patients who took less analgesics in groups A,B and C were 1,3 and 6 respectively.Evaluation at 8 weeks found obvious difference between groups B,C and group A( P <0.05, P <0.005),but no difference between group B and group C.Evaluation at 12 weeks found that the effective rates of groups A,B and C were 61.5%,88.0% and 92.0% respectively.Conclusion High dosage of sodium ibandronate has faster,longer and better efficacy than low dosage in treating bone metastasis pain.
出处
《中国肿瘤临床与康复》
2004年第6期574-576,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肿瘤
伊班膦酸钠
骨转移
疼痛
Neoplasms
Sodium Ibandronate
Bone metastasia
Pain