人尿中1-羟基芘浓度与多环芳烃日暴露量的关系

RELATIONSHIP BETWEEN URINARY 1-HYDROXYPYRENE AND TOTAL PERSONAL DAILY EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS

采集并分析了 10 0名不吸烟成人 2 4h的呼吸带空气 (PM10 和气相 )、食物及尿液样品 ,建立了尿中1 羟基芘与多环芳烃日暴露量的关系 结果表明 :晨尿 1 羟基芘 (μmol·mol肌酐 -1)浓度与芘、苯并 (a )芘等 13种多环芳烃日暴露量的对数线性回归方程拟合度R2 达 0 12— 0 6 7,方程各项参数也均达到了显著性水平 (P <0 0 0 1)

Urinary 1-hydroxypyrene may be used as a biomarker of human exposure to PAHs, a group of carcinogenic compounds. Quantitative relationships between 1-hydroxypyrene and personal daily exposure to PAHs including both inhalation and ingestion are very useful in assessing PAHs exposure risk.However, such quantitative relationships are currently lacking. We selected 100 non-smoking adults who may have different PAH exposure levels.Their 24h personal air, 24h food, and 24h urine samples were all collected and analyzed. We established quantitative equations between urinary 1-hydroxy- pyrene (μmol·mol creatinine -1) and personal daily exposure to pyrene, benzo(a)pyrene and other PAHs compounds by linear regression. The R 2 values for these regressions ranged from 0.12 to 0.67 (P<0.001).