C-反应蛋白与急性冠脉综合征关系的研究

Correlation Between C - Reactive Protein and Acute Coronary Syndrome

目的研究C-反应蛋白(CRP)在急性冠状脉综合征(ACS)病人血清中的变化及其相关性。方法 采用免疫透射比浊法对182例急性冠脉综合征病人及60例正常人外周血清中CRP水平进行测定。结果患者组CRP值明显高于对照组(P<0.01),而急性心肌梗死(AMI)组与不稳定型心绞痛(UA)组CRP值有显著差异性(P<0.05)。经logis-tic回归分析显示CRP的风险(OR)比值均大于1,是急性冠脉综合征(ACS)的危险因素。结论 急性冠脉综合征病人CRP升高是急性冠脉综合征发生和发展的独立危险因素;可作为其预后的指标。

Objective To study the changes of C- reactive protein (CRP) level in acute coronary syndrome (ACS) and their correlation. Methods The levels of CRP in peripheral serum of 82 ACS patients and 60 normal control were measured respectively by scatter rate turbidity. Results The levels of CRP in ACS group were higher than that in control group(P< 0. 01). There was significant difference in the level of CRP between AMI subgroup and UA subgroup(P<0.05). Logistic regression analysis showed that the odds ratio(OR) of CRP was> 1, indicating that CRP was risk factor. CRP was independent in the course of ACS. Conclusions The increase of CRP is independent risk factor in morbidity and development of ACS. As an index, CRP can be used in the estimation of prognosis.