巨和粒治疗肿瘤患者放化疗后血小板下降的临床观察

Clinical Observation of Juheli on Thrombopenia of the Patients After Chemotherapy and Radiotherapy

目的 观察巨和粒 (重组人白细胞介素 11)治疗肿瘤患者放化疗后血小板减少症的临床疗效。方法 对 2 6例放化疗后血小板减少的肿瘤患者进行随机分组观察 ,治疗组 15例 ,应用巨和粒 5 0 μg/(kg d)皮下注射 ,直至血小板数量达到≥ 80× 10 9/L ;对照组11例 ,不治疗 ,观察血小板计数和血小板恢复时间。结果 给药第 6天 ,第 10天 ,治疗组血小板计数均显著高于对照组 (P <0 0 0 1)。血小板计数恢复到 80× 10 9/L以上所需时间治疗组较对照组显著缩短 (P <0 0 0 2 )。

Objective To observe the clinical effects of Juheli(rhIL-11) on thrombopenia of the patients with malignant tumor after chemotherapy and radiotherapy. Methods 26 patients with malignant tumor suffering from thrombopenia after chemotherapy and radiotherapy were randomly divided into Juheli group (n=15) which received hypodermic injection Juheli 50μg/(kg.d) till the thrombocyte count reached ≥ 80×10 9/L, and control group (n=11) which received no therapy. Thrombocyte count and thrombocyte recovery time were observed. Results Thrombocyte count of Juheli group was obviously higher than that of control group at the 6 days and the 10 days(P<0.001). The time needed to recover thrombocyte count over 80×10 9/L was shortened compared with control group(P<0.002). Conclution Juheli can effectively improve thrombopenia of the patients with malignant tumor after chemotherapy and radiotherapy.