眼基因治疗中载体的选择
摘要
基因治疗是目前生命科学领域研究的热点之一。基因治疗的关键因素是如何将目的基因导入相应靶器官,并安全、有效地表达。本文就眼基因治疗中,各种载体的生物学特性进行综述。
出处
《国外医学（眼科学分册）》
2004年第6期370-373,共4页
Foreign Medical Sciences(Section of Ophthalmology )
参考文献22
-
1Bielinska A, Kukowska-Latallo JF, Johnson J,et al. Regulation of in vitro gene expression using antisense oligonucleotide or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res, 1996,24:2176-2182.
-
2Rudich SM, Zhou S, Srivastava R, et al. Dose response to a single intramuscular injection of recombinant adeno-associated viruserythropoietin in monkeys. J Surg Res, 2000,90:102-108.
-
3Xiao X, Li J, Samulski RJ. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus.J Virol, 1998,72:2224-2232.
-
4Hermonant PL, Muzyczka N. Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells. Proc Natl Acad Sci USA, 1984,81:6466-6470.
-
5Liu D, Knapp JE. Hydrodynamics-based gene delivery. Curr Opin Mol Ther, 2001, 3:192-197.
-
6Hauswirth WW, Beaufrere L. Ocular gene therapy: quo vadis? Invest Ophthalmol Vis Sci, 2000,41: 2821-2826.
-
7Monahan PE, Samulski RJ. Adeno-associated virus vectors for gene therapy: more pros than cons? Mol Med Today, 2000,6:433-440.
-
8Samulski RJ, Zhu X, Xiao X, et al. Targeted integration of adenoassociated virus (AAV) into human chromosome 19. EMBO J,1991,10:3940-3950.
-
9Conrad CK, Allen SS, Afione SA, et al. Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung. Gene Ther, 1996,3:658-668.
-
10Langer JC, Klotman ME, Hanss B, et al. Adeno-associated virus gene transfer into renal cells: potential for in vivo gene delivery.Exp Nephrol, 1998,6:189-194.
-
1李煜,综述,钱关祥,审校.基因治疗中的病毒性载体研究进展[J].上海第二医科大学学报,2000,20(3):280-282.
-
2王莉娜,葛坚,黄冰.基因打靶技术及其在眼科领域的应用[J].国际眼科纵览,2006,30(1):2-6.
-
3张斌.眼科疾病的铜绿假单胞菌的临床分布及耐药性分析[J].天津医药,2013,41(10):1028-1029. 被引量：4
-
4James M Wilson.病毒预防靠病毒[J].中华生物医学工程杂志,2007,13(3):127-128.
-
5许晓楠,张红梅,安利佳.基因治疗中载体的研究进展[J].医学新知,2001,11(4):199-201. 被引量：1
-
6王祎琴,洪苏玲.重组腺病毒相关病毒载体基因治疗研究进展[J].重庆医学,2006,35(2):179-182. 被引量：2
-
7刘骁,唐罗生.眼科研究发展的新契机：转化医学-从基础走向临床[J].中华眼科杂志,2009,45(3):276-279. 被引量：1
-
8Paddy Horner,许可见（译）,刘跃华（校）.沙眼衣原体和非淋球菌性尿道炎[J].国际内科双语杂志（中英文）,2006,6(4):15-17.
-
9李雅军.源自眼科疾病的表皮葡萄球菌的耐药性分析[J].天津医药,2009,37(7):617-618. 被引量：1
-
10陈洁,潘志强.骨髓间充质干细胞治疗眼科疾病的临床前研究进展[J].中华眼科杂志,2008,44(11):1050-1054. 被引量：1
