2型糖尿病患者及糖耐量正常的一级亲属血浆纤溶酶原激活物抑制物与胰岛素抵抗的相关性研究

Correlation of plasma activator of plasminogen inhibitor with insulin resistance in the first degree relatives of type 2 diabetics

目的 通过检测 2型糖尿病 (T2DM)及糖耐量正常的一级亲属 (FDRs)血浆纤溶酶原激活物抑制物 - 1 (PAI- 1 )活性 ,分析它们与血脂、血糖、体重指数 (BMI)、腰臀比 (WHR)、胰岛素抵抗 (IR)之间关系。方法 采用发色底物法测PAI- 1活性 ,稳态模型胰岛素抵抗指数来评估胰岛素抵抗。结果 T2DM组PAI- 1活性显著高于对照组及FDRs组 ,有显著性差异 (P <0 .0 1 ) ;且FDRs组显著高于对照组 ,有显著性差异 (P <0 .0 5 )。结论 T2DM及糖耐量正常的 2型糖尿病FDRs血浆PAI- 1活性升高 ,且PAI- 1活性与胰岛素抵抗密切相关。因此 ,PAI- 1在T2DM的发生发展中扮演着重要的作用。

Objective To study changes of plasma plasminogen activator inhibitor type-1 (PAI-1) activity in type 2 diabetes mellitus (T2DM) and NGT first degree relatives (FDRs) of T2DM. Methods Fasting plasma PAI-1 activity was measured by the synthetic chromogenic method using a colorimetric assay, which were determined in T2DM patients, NGT FDRs of T2DM, as well as normal controls. Results The level of plasma PAI-1 activity was significantly higher in both T2DM and FDRs than that in control group (P<0.05) . Conclusions PAI-1 may play an important role in the development of T2DM.