那格列奈治疗2型糖尿病的疗效及安全性

Therapeutic effect and safety of nateglinide in management of 2 type diabetes mellitus

目的 观察那格列奈治疗 2型糖尿病的疗效及安全性。方法 经 4周清洗期后符合标准的 5 8例患者随机分为那格列奈组 (2 8例 )和瑞格列奈组 (30例 ) ,治疗前后测定空腹血糖(FBS)、餐后 2h血糖 (PBS)、糖化血红蛋白 (HbA1 c)及肝、肾功能等。结果 那格列奈组治疗后FBS、PBS和HbA1 c均显著下降 (P <0 .0 1 ) ,与瑞格列奈组比较无显著性差异。两组均无肝肾功能损害。结论 那格列奈有明确的降低空腹、餐后血糖及糖化血红蛋白的作用 ,不良反应少 ,是一种安全、有效的降糖药物。

Objective To evaluate efficacy and safety of nateglinide in type 2 diabetes patients. Methods After a four-week washout period, 58 recruited patients with type 2 diabetes were randomly assigned to nateglinide (28 cases) and repaglinide (30 cases) treatment group. Results The fasting and 2 hours postprandial blood glucose and HbA 1c levels decreased significantly after 12 weeks treatment with nateglinide (P<0.01).There was no significant differences between the groups. Conclusion Nateglinide has the effect of improving glucose metabolism. It is an efficacy and safety drug in the treatment of diabetes.