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脑星形胶质细胞瘤Bcl-2、P16表达的临床病理分析 被引量：5

EXPRESSION OF BCL-2 AND P16 IN BRAIN ASTROCYTOMA WITH THEIR CLINICOPATHOLOGICAL FEATURE
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摘要 目的:探讨Bcl-2和P16的表达与脑星形胶质细胞瘤的病理组织学分级的关系。方法　应用免疫组 织化学技术S-P法检测40例脑星形胶质细胞瘤(Ⅰ-Ⅱ级18例,Ⅲ-Ⅳ级22例)中Bcl-2和P16蛋白的 表达。结果　Bcl-2和p16与脑星形胶质细胞瘤的组织学分级呈负相关,低级别组(Ⅰ-Ⅱ级)和高级别组 (Ⅲ-Ⅳ级)之间差异有显著性。结论　Bcl-2和P16在脑星形胶质细胞瘤的早期阶段即参与肿瘤的发生 发展。 purpose:To investigate the expression of Bcl-2 and P16 in brain astrocytoma with their grade of pathological organization.Methods: the expression of Bcl-2 and P16 was detected in 40 cases of brain astrocytoma by S-P immunohistochemical technique.Results: Among 40 brain astrocytoma,there was a reverse relevant between Bcl-2、P16 and their grade of pathological organization.Condusions: Bcl-2 and P16 are involved in early stage of brain astrocytoma.
作者 王宗龙 郭雪西 董艳杰 王茜
机构地区 牡丹江市第一人民医院
出处 《牡丹江医学院学报》 2005年第1期18-19,共2页 Journal of Mudanjiang Medical University
关键词 脑肿瘤 星形胶质细胞瘤 蛋白质BCL-2 蛋白质P16 免疫组织化学 brain neoplasms astrocytoma protein Bcl-2 protein P16 immunohistochemistry
分类号 R739.41 [医药卫生—肿瘤]
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共引文献9

同被引文献29

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引证文献5

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牡丹江医学院学报
2005年 第1期

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