摘要
The mechanism of enhancers （methanol,chloroform,azone and thiozone） was studied in vitro in mouse stratum corneum （SC）.Attenuated total reflectance Fourier-transform infrared spectroscopy （ATR-FTIR） was applied to monitor the wavenumber shifts of CH2 stretching absorbance as well as the lipid content in the SC,which were used as criteria to explain the effect of the enhancers on mouse SC.The FTIR spectra record that treatment with these four enhancers would result in significant shifts toward higher wavenumber at vasCH2 and vsCH2 and the integration areas of vasCH2 and vsCH2 decrease when treatment of methanol and choloroform.It is concluded that these four enhancers could increase the gauche conformational isomer content of lipid CH2,made the lipid in the SC a more fluid state,thus the resistance of drug transdermal delivery was reduced.
The mechanism of enhancers (methanol,chloroform,azone and thiozone) was studied in vitro in mouse stratum corneum (SC).Attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) was applied to monitor the wavenumber shifts of CH_2 stretching absorbance as well as the lipid content in the SC,which were used as criteria to explain the effect of the enhancers on mouse SC.The FTIR spectra record that treatment with these four enhancers would result in significant shifts toward higher wavenumber at v_(as)CH_2 and v_sCH_2 and the integration areas of v_(as)CH_2 and v_sCH_2 decrease when treatment of methanol and choloroform.It is concluded that these four enhancers could increase the gauche conformational isomer content of lipid CH_2,made the lipid in the SC a more fluid state,thus the resistance of drug transdermal delivery was reduced.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2005年第1期64-65,共2页
Chemical Research and Application
基金
国家重点基础研究发展规划项目(G199954305)
