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3T磁共振波谱在胶母细胞瘤和单发转移瘤鉴别诊断中的应用 被引量:5

Glioblastoma Multiforme and Solitary Metastases:Differential Diagnosis by 3T MR Spectroscopic Imaging
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摘要 探讨在体3.0T二维磁共振波谱成像技术对颅内胶母细胞瘤和单发转移瘤的鉴别诊断价值。材料和方法选择诊断明确的20例患者(胶母细胞瘤12例,单发转移瘤8例)行3.0T磁共振扫描。在常规平扫完成后行二维多体素波谱扫描,后进行常规造影剂增强检查。波谱扫描的感兴趣区包括肿瘤的实质、囊变坏死、瘤周水肿部分以及病灶的对侧,瘤周水肿区域是从病灶强化的边缘开始,利用多体素连续测量其代谢变化。t-test来统计所有的半定量数据。结果①胶母细胞瘤和单发转移瘤的瘤体实质波谱检查无明显差异;②比较紧邻瘤体强化实质的瘤周水肿区域和病灶对侧的波谱表现,两种肿瘤均有差异;③比较稍远离肿瘤强化实质的瘤周区域(和肿瘤强化边缘相距7.5mm)和病灶对侧之间的波谱表现,Cho/Cr在胶母细胞瘤仍有差异(1.512±0.162vs0.919±0.056),在单发转移瘤无明显差异(1.237±0.157vs0.86±0.139)。结论高度恶性的胶母细胞瘤和单发转移瘤的多体素波谱表现在肿瘤实质之间无明显差异;瘤周水肿区域的波谱检查对于两种肿瘤的鉴别诊断有意义。 Purpose:To evaluate the value of3T MR spectroscopic imaging in the differential diagnosis between the GBMs(glioblastoma multiforme)and the solitary metastases.Materials and Methods:Twenty patients(12cases of GBMs and8cases of metastases)underwent3T MR spectroscopic imaging examination beˉfore operation or biopsy.The ROI(region of interest)include the mass,the peritumoral edematous reˉgion(hyperintense in T 2 weighted imaging but no enhancing in the post-contrast T 1 weighted imaging)and the opposite side.Continuous measurements of enhancing tumor and peritumoral edematous region obtained from the spectra.The student t-test was used to determine if there was a statistically signifˉicant difference in the spectra between GBMs and metastases.Results:①No statistically significant difference was found between the parenchymatous parts of the tumors.②The difference of Cho/Cr beˉtween the peritumoral edematous region closely adjacent to the enhancing border of the tumor and the opposite side were found statistically significant in GBMs and metastases.③The difference of Cho/Cr between the edematous region7.5mm(the width of a voxel)apart from the enhancing tumor border and the opposite side was statistically significant in the GBMs(1.512±0.162vs0.919±0.056),but not statistiˉcally significant in the metastases(1.237±0.157vs0.86±0.139).Conclusion:The spectra of the parenchymatous part of the tumor showed no statistically significant difference in GBMs and metastases.The continuous spectroscopic measurements of peritumoral edematous region can do help in the differential diagnosis between GBMs and solitary metastases.
出处 《中国医学计算机成像杂志》 CSCD 2004年第6期361-365,共5页 Chinese Computed Medical Imaging
关键词 3T磁共振波谱 胶母细胞瘤 单发转移瘤 鉴别诊断 Magnetic resonance spectroscopy Glioblastoma multiforme Solitary metastases Diagnosis Differential diagnosis
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  • 1Majos C,Alonso J,Aguilera C, et al. Proton magnetic resonance spectroscopy of human brain tumours:assessment of differences between tumour types and its applicability in brain tumour categorization. Eur Radiol 2003; 13: 582~ 591
  • 2Podo F, Henriksen O, Bovee WMMJ. Absolute metabolite quantification by in vivo NMR spectroscopy: I. introduction, objectives and activities of concerted action in biomedical research. Magn Reson Imaging 1998; 16: 1085~ 1092
  • 3Law M,Yang S,Wang H, et al. Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR Imaging.AJNR 2003; 24:1989~ 1998
  • 4Keevil SF, Barbiroli B, Brooks JCW. Absolute metabolite quantification by in vivo NMR spectroscopy:Ⅱ . a multicenter trials of protocols for in vivo localized proton studies of human brain. Magn Reson Imaging 1998; 16: 1093~ 1106
  • 5Beer RD, Barbiroli B, Gobbi G.Absolute metabolite quantification by in vivo NMR spectroscopy:Ⅲ .multicenter 1H MRS of the human brain addressed by one and the same data- analysis protocol. Magn Reson Imaging 1998; 16: 1107~ 1111
  • 6Negendank WG,Sauter R,Brown TR,et al.Proton magnetic resonance spectroscopy in patients with glial tumors:a multicenter study.J Neurosurg 1996;84:449- 458
  • 7Lukas L, Devos A, Suykens JAK, et al. Brain tumor classification based on long echo proton MRS signals. Artif Intell Med 2004; 31:73- 89
  • 8Rabinov JD, Lee PL, Barker FG, et al. In vivo 3- T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology 2002; 225:871- 879
  • 9Law M, Cha S, Knopp EA. High- grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology 2002; 222: 715- 721
  • 10Meyerand ME, Pipas JM, Mamourian A, et al. Classification of biopsy confirmed brain tumors using single- voxel MR spectroscopy. AJNR 1999; 20: 117- 123

同被引文献39

  • 1彭涛,伍兵,肖建明.磁共振波谱与扩散加权成像技术诊断前列腺癌的比较研究[J].四川大学学报(医学版),2013,44(5):827-831. 被引量:6
  • 2雷皓,魏黎,刘买利.磁共振波谱及成像技术在纳米尺度物质生物效应研究中的应用[J].物理,2006,35(4):294-298. 被引量:1
  • 3周高峰,王小宜,廖伟华,王润文,龚才桂,贾高志.氢质子磁共振波谱鉴别孤立脑转移瘤与高级别脑胶质瘤的临床应用价值[J].实用放射学杂志,2007,23(1):1-5. 被引量:11
  • 4Moller-Hartmann W, Herminghaus S, Krings T, et al. Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions [J]. Neuroradiology, 2002, 44: 371-381.
  • 5Law M, Cha S, Knopp EA, et al. High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging[J]. Radiology, 2002, 222: 715-721.
  • 6Warren KE. NMR Spectroscopy and Pediatric Brain Tumors. The Oncologist ,2004,9 : 312
  • 7Magalhaes A,Godfrey W,Shen Y, et al. Proton Magnetic Resonance Spectroscopy of Brain Tumors Correlated With Pathology. Acad Radiol,2005 ,12 :51
  • 8Tare AR, Majos C, Moreno A, et al. Automated classification of short echo time in in vivo ^1H brain tumor spectra: a multicenter study. Magn Reson Med,2003,49:29
  • 9Ricci PE, Pitt A, Keller PJ, et al. Effect of voxel position on singlevoxel MR spectroscopy findings. AJNR,2000,21 : 367
  • 10Burtscher IM, Skagerberg G, Geijer B,et al. Proton MR spectroscopy and preoperative diagnostic accuracy: an evaluation of intracranial mass lesions characterized by stereotactic biopsy findings. AJNR, 2000,21:84

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