摘要
探讨在体3.0T二维磁共振波谱成像技术对颅内胶母细胞瘤和单发转移瘤的鉴别诊断价值。材料和方法选择诊断明确的20例患者(胶母细胞瘤12例,单发转移瘤8例)行3.0T磁共振扫描。在常规平扫完成后行二维多体素波谱扫描,后进行常规造影剂增强检查。波谱扫描的感兴趣区包括肿瘤的实质、囊变坏死、瘤周水肿部分以及病灶的对侧,瘤周水肿区域是从病灶强化的边缘开始,利用多体素连续测量其代谢变化。t-test来统计所有的半定量数据。结果①胶母细胞瘤和单发转移瘤的瘤体实质波谱检查无明显差异;②比较紧邻瘤体强化实质的瘤周水肿区域和病灶对侧的波谱表现,两种肿瘤均有差异;③比较稍远离肿瘤强化实质的瘤周区域(和肿瘤强化边缘相距7.5mm)和病灶对侧之间的波谱表现,Cho/Cr在胶母细胞瘤仍有差异(1.512±0.162vs0.919±0.056),在单发转移瘤无明显差异(1.237±0.157vs0.86±0.139)。结论高度恶性的胶母细胞瘤和单发转移瘤的多体素波谱表现在肿瘤实质之间无明显差异;瘤周水肿区域的波谱检查对于两种肿瘤的鉴别诊断有意义。
Purpose:To evaluate the value of3T MR spectroscopic imaging in the differential diagnosis between the GBMs(glioblastoma multiforme)and the solitary metastases.Materials and Methods:Twenty patients(12cases of GBMs and8cases of metastases)underwent3T MR spectroscopic imaging examination beˉfore operation or biopsy.The ROI(region of interest)include the mass,the peritumoral edematous reˉgion(hyperintense in T 2 weighted imaging but no enhancing in the post-contrast T 1 weighted imaging)and the opposite side.Continuous measurements of enhancing tumor and peritumoral edematous region obtained from the spectra.The student t-test was used to determine if there was a statistically signifˉicant difference in the spectra between GBMs and metastases.Results:①No statistically significant difference was found between the parenchymatous parts of the tumors.②The difference of Cho/Cr beˉtween the peritumoral edematous region closely adjacent to the enhancing border of the tumor and the opposite side were found statistically significant in GBMs and metastases.③The difference of Cho/Cr between the edematous region7.5mm(the width of a voxel)apart from the enhancing tumor border and the opposite side was statistically significant in the GBMs(1.512±0.162vs0.919±0.056),but not statistiˉcally significant in the metastases(1.237±0.157vs0.86±0.139).Conclusion:The spectra of the parenchymatous part of the tumor showed no statistically significant difference in GBMs and metastases.The continuous spectroscopic measurements of peritumoral edematous region can do help in the differential diagnosis between GBMs and solitary metastases.
出处
《中国医学计算机成像杂志》
CSCD
2004年第6期361-365,共5页
Chinese Computed Medical Imaging
关键词
3T磁共振波谱
胶母细胞瘤
单发转移瘤
鉴别诊断
Magnetic resonance spectroscopy Glioblastoma multiforme Solitary metastases Diagnosis Differential diagnosis