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2型糖尿病患者空腹血清真胰岛素水平和胰岛素抵抗与血脂的关系 被引量:5

A study on the relation of serum fasting true insulin level and insulin resistance with serum lipids in patients with type 2 diabetes mellitus
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摘要 目的 探讨 2型糖尿病 (T2DM )患者空腹血清真胰岛素水平、胰岛素抵抗与血脂的关系。 方法 应用BA ELISA法测定正常糖耐量 (NC)组 96例、T2DM组 132例和T2DM伴原发性高血压 (T2DM +EH)组 14 8例的空腹血清真胰岛素 (TI)水平 ,酶法检测血脂 ,计算胰岛素抵抗指数(HOMA IR)、β细胞功能指数 (HOMA β)。  结果 T2DM组及T2DM +EH组的甘油三酯 (TG)、HOMA IR高于NC组 ,高密度脂蛋白胆固醇 (HDL C)和HOMA β低于NC组 ,差异均有显著意义 (P<0 0 5 )。T2DM +EH组HOMA IR高于T2DM组 ,差异有显著意义 (P <0 0 5 )。T2DM组及T2DM+EH组的TG与TI、HOMA IR呈正相关 (P <0 0 1) ,HDL C与TI、HOMA IR呈负相关 (P <0 0 5 )。 结论 T2DM患者空腹血清TI水平与脂代谢异常相关 ,血清TI水平的升高和 (或 )IR的加重均会引起TG升高和HDL C降低。IR与脂代谢异常及高血压的关系较高TI血症更密切。 Objective To explore the relationship of serum fasting true insulin (TI) level and insulin resistance (IR) with lipids in patients with type 2 diabetes(T2DM) Methods The fasting TI was determined with BA ELISA method, blood lipids and blood glucose(PG) with an enzyme method in 96 subjects with NC, 132 subjects with T2DM and 148 subjects with T2DM accompanying primary hypertension(T2DM+EH), who did not undergo any antidyslipidemia treatment for a month and antihypertensive treatment for two weeks On the basis of FPG and TI, insulin secretion function (HOMA β) and IR level (HOMA IR) were calculated Results TG and HOMA IR in both T2DM and T2DM+EH groups were significantly higher than those in NC group ( P <0 01) HDL C, HOMA β in T2DM and T2DM+EH groups were significantly lower than those in NC group ( P <0 05) HOMA IR in T2DM+EH group was significantly higher than that in T2DM group HOMA β in T2DM+EH group was higher than that in T2DM group, but the difference was not significant TG had statistically significant positive correlation with TI and HOMA IR( P <0 01), HDL C had statistically negative correlation with TI and HOMA IR ( P <0 05) in both T2DM and T2DM+EH Conclusion Serum true insulin level and insulin resistance are associated with dyslipidemia in type 2 diabetes The elevated true insulin and/or serious insulin resistance will elevate TG and decrease HDL C Insulin resistance is more associated with dyslipidemia than truly hyperinsulinemia
出处 《中华糖尿病杂志(1006-6187)》 CSCD 2004年第6期402-404,共3页
基金 辽宁省自然科学基金资助项目 (9910 5 0 0 3 0 2 )
关键词 T2DM 空腹 血清 EH 真胰岛素 血脂 患者 IR HDL-C 胰岛素抵抗 Diabetes mellitus, type 2 Dyslipidemia True insulin Insulin resistance
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  • 1Temple RC, Clark PMS, Nagi DK, et al. Radioimmunoassay may overestimate insulin in non-insulin-dependent diabetics. Clin Endocrinol, 1990,32:689-693.
  • 2Clark P, Hales C. How to measure plasma insulin. Diabetes Metab Rev, 1994,10:79-90.
  • 3Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell fuction from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985,28:412-419.
  • 4UK prospective diabetes study group. Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex: UKPDS 27. Diabetes Care, 1997,20:1683-1687.
  • 5Salonen JT, Lakka TA, Lakka HM, et al. Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men. Diabetes, 1998,47:270-275.
  • 6Yokota C, Ikebuchi M, Suzuki M, et al. Insulin resistance rather than hyperinsulinemia more closely associated with essential hypertension. Clin Exp Hypertens, 1995,17:523-536.
  • 7Ogihara T, Rakugi H, Ikegami H, et al. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am J Hypertens, 1995,8:316-320.

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  • 1周鹏,张燕,西琳,阿塔汗,葛娟,叶尔肯,朱大龙.伊犁地区多民族人群血清甘油三酯分布特点及其与糖代谢异常的关系[J].中华内科杂志,2006,45(4):302-305. 被引量:8
  • 2俞璐,徐伟斌,罗敏.糖毒性血管损伤的研究进展[J].中国实用内科杂志:临床前沿版,2006,26(1):136-138. 被引量:7
  • 3王岚,滕云,裘秀菊.在职知识分子2型糖尿病的危险因素分析[J].浙江临床医学,2006,8(5):450-451. 被引量:2
  • 4张晓 高鹏芹.控制血糖对血脂、载脂蛋白及心血管并发症的影响[J].实用糖尿病杂志,1999,2(1):46-46.
  • 5王玉珍,王爱红,赵湜,李强,王鹏华,严励,李翔,杜玉茗,卞茸文,王战建,毛季萍,肖正华,马学毅,林少达,陈国昌,周迎生,史琳涛,许樟荣.中国南方与北方地区糖尿病足病危险因素分析[J].中华医学杂志,2007,87(26):1817-1820. 被引量:36
  • 6[2]UK Prospective Diabetes Study.Hight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes:UKPDS 38.BMJ,1998,317:703-713.
  • 7[3]UK prospective diabetes study group Plasma lipids and lipoproteina at diagnosis of NIDDM by age and sex:UKPDS 27.Diabetes Care,1997,20:1683-1687.
  • 8[4]Salonen JT,Lakka TA,Lakka HM,et al.Hyperinaulinemia is associated with the incidence of hypertension and dyslipidemia in middleaged men.Diabetes,1998,47:270-275.
  • 9[6]Salonen JT,Lakka TA,Lakka HM,et al.Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middleaged men.Diabetes,1998,47:270-275.
  • 10[7]Hanefeld M,Fischer S,Julius U,et al.Risk factors for Myocardial infarction and death in newly detected NIDDM:the diabetes intervention study,11-year follow-up.Diabetologia,1996,39:1577-1583.

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